Protein Alignment Cdk2 and MAPK15

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: XP_011515227.1
• Gene: MAPK15 / 225689
• HGNCID: 24667
• Length: 565
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 113/304 - (37%)
• Similarity: 168/304 - (55%)
• Gaps: 41/304 - (13%)

  Fly    19 YGIVYKARSNSTGQDVALKKI------RLEGETEG---VPST----------AIREISLLKNL-K 63
            ||||:||....||:.||:|||      :.:.:..|   .|.|          ..|||:||:.. .
Human    26 YGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQDMGFLLAPPTHTPVFLSLQRTFREITLLQEFGD 90

  Fly    64 HPNVVQLFDVVISGN--NLYMIFEYLNMDLKKLMDK---KKDVFTPQLIKSYMHQILDAVGFCHT 123
            |||::.|.||:.:.|  ::|::||:::.||..::.|   .:||.    ::|..:|:|.|..|.|:
Human    91 HPNIISLLDVIRAENDRDIYLVFEFMDTDLNAVIRKGGLLQDVH----VRSIFYQLLRATRFLHS 151

  Fly   124 NRILHRDLKPQNLLVDTAGKIKLADFGLARAF-NVPM----RAYTHEVVTLWYRAPEILLGTKFY 183
            ..::|||.||.|:|:|....:||.||||||:. ::|.    :|.|..|.|.||||||:||.:..|
Human   152 GHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRY 216

  Fly   184 STGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGV------TQLPDFKTK 242
            :.|||:||||||..||:..|.||||.|.:.||..|..|:..|.|.:...:      :.|....::
Human   217 TLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSR 281

  Fly   243 FPRWEGTNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAY 286
             ||.....:..|.|..||.:|:..:|.:.|:.|:||..||||.|
Human   282 -PRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPY 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	113/304 (37%)
MAPK15	XP_011515227.1	STKc_MAPK15-like	25..364	CDD:270841	113/304 (37%)