Protein Alignment Cdk2 and Cdk4

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_034000.1
• Gene: Cdk4 / 12567
• MGIID: 88357
• Length: 303
• Species: Mus musculus
• Alignment Length: 293
• Identity: 128/293 - (43%)
• Similarity: 182/293 - (62%)
• Gaps: 18/293 - (6%)

  Fly     8 FQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLE---GETEGVPSTAIREISLLKNL---KHPN 66
            ::...:||.|.||.|||||...:|..||||.:|:.   ....|:|.:.:||::||:.|   :|||
Mouse     6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEAFEHPN 70

  Fly    67 VVQLFDVVISGN-----NLYMIFEYLNMDLKKLMDKKKDVFTP-QLIKSYMHQILDAVGFCHTNR 125
            ||:|.||..:..     .:.::||:::.||:..:||......| :.||..|.|.|..:.|.|.|.
Mouse    71 VVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFLSGLDFLHANC 135

  Fly   126 ILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIW 190
            |:||||||:|:||.:.|.:|||||||||.::..| |.|..||||||||||:||.:. |:|.||:|
Mouse   136 IVHRDLKPENILVTSNGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQST-YATPVDMW 198

  Fly   191 SLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLP--DFKTKFPRWEGTNMPQ 253
            |:||||:||..|:.||.|:||.|||.:||..:..|.|.:||....||  .|..:.||...:.:|:
Mouse   199 SVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVSLPRGAFAPRGPRPVQSVVPE 263

  Fly   254 PITEHEAHELIMSMLCYDPNLRISAKDALQHAY 286
              .|....:|::.||.::|:.||||..||||:|
Mouse   264 --MEESGAQLLLEMLTFNPHKRISAFRALQHSY 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	128/293 (44%)
Cdk4	NP_034000.1	STKc_CDK4	5..295	CDD:143368	128/293 (44%)
		Required for binding D-type cyclins. /evidence=ECO:0000250	50..56		1/5 (20%)