Protein Alignment Cdk2 and Cdk6

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_001178790.1
• Gene: Cdk6 / 114483
• RGDID: 621121
• Length: 326
• Species: Rattus norvegicus
• Alignment Length: 311
• Identity: 132/311 - (42%)
• Similarity: 197/311 - (63%)
• Gaps: 35/311 - (11%)

  Fly     6 DNFQRAE-------KIGEGTYGIVYKARS-NSTGQDVALKKIRLEGETEGVPSTAIREISLLKNL 62
            |:..||:       :||||.||.|:|||. .:.|:.||||::|::...||:|.:.|||:::|::|
  Rat     4 DSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68

  Fly    63 ---KHPNVVQLFDV-VISGNN----LYMIFEYLNMDLKKLMDKKKDVFTP-QLIKSYMHQILDAV 118
               :|||||:|||| .:|..:    |.::||:::.||...:||..:...| :.||..|.|:|..:
  Rat    69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGL 133

  Fly   119 GFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFY 183
            .|.|::|::||||||||:||.::|:||||||||||.::..| |.|..||||||||||:||.:. |
  Rat   134 DFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPEVLLQSS-Y 196

  Fly   184 STGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLP--DFKTKFPRW 246
            :|.||:||:||||:|:..|:.||.|.|::|||.:|...:..|.|.:||....||  .|.:|
  Rat   197 ATPVDLWSVGCIFAELFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSK---- 257

  Fly   247 EGTNMPQPI------TEHEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQ 291
                ..|||      .:....:|::..|.::|..||||..||.|.||::::
  Rat   258 ----SAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLE 304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	129/303 (43%)
Cdk6	NP_001178790.1	STKc_CDK6	11..300	CDD:270846	127/298 (43%)