Protein Alignment Cdk2 and CDK7

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_001790.1
• Gene: CDK7 / 1022
• HGNCID: 1778
• Length: 346
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 127/287 - (44%)
• Similarity: 184/287 - (64%)
• Gaps: 6/287 - (2%)

  Fly     8 FQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETE---GVPSTAIREISLLKNLKHPNVVQ 69
            :::.:.:|||.:..|||||..:|.|.||:|||:|...:|   |:..||:|||.||:.|.|||::.
Human    12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQ 134
            |.|.....:|:.::|:::..||:.::.....|.||..||:||...|..:.:.|.:.||||||||.
Human    77 LLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPN 141

  Fly   135 NLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM 199
            |||:|..|.:||||||||::|..|.|||||:|||.||||||:|.|.:.|..|||:|::|||.:|:
Human   142 NLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAEL 206

  Fly   200 IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQPITE--HEAHE 262
            ::|....||||::|||.|||.||.||.|..||.:..|||:.| |..:.|..:....:.  .:..:
Human   207 LLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT-FKSFPGIPLHHIFSAAGDDLLD 270

  Fly   263 LIMSMLCYDPNLRISAKDALQHAYFRN 289
            ||..:..::|..||:|..||:..||.|
Human   271 LIQGLFLFNPCARITATQALKMKYFSN 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	124/283 (44%)
CDK7	NP_001790.1	STKc_CDK7	11..308	CDD:270833	127/287 (44%)