Protein Alignment Cdk2 and CDK5

DIOPT Version :10

• Sequence 1: NP_524420.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 145/287 - (50%)
• Similarity: 201/287 - (70%)
• Gaps: 5/287 - (1%)

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            :..:::.|||||||||.|:||::..|.:.||||::||:.:.|||||:|:|||.|||.|||.|:|:
Human     1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 65

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQ 134
            |.||:.|...|.::||:.:.||||..|.......|:::||::.|:|..:||||:..:||||||||
Human    66 LHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQ 130

  Fly   135 NLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM 199
            |||::..|::|||||||||||.:|:|.|:.||||||||.|::|.|.|.|||.:|:||.||||:|:
Human   131 NLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 195

  Fly   200 I-MRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNM---PQPITEHEA 260
            . ..|.||||:...|||.||||.|.||.|..||.:|:|||:| .:|.:..|..   ..|......
Human   196 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK-PYPMYPATTSLVNVVPKLNATG 259

  Fly   261 HELIMSMLCYDPNLRISAKDALQHAYF 287
            .:|:.::|..:|..||||::||||.||
Human   260 RDLLQNLLKCNPVQRISAEEALQHPYF 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_524420.1	STKc_CDK1_CdkB_like	8..287	CDD:270829	143/282 (51%)
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	143/283 (51%)