Protein Alignment Cdk2 and CDK2

DIOPT Version :9

• Sequence 1: NP_001163666.1
• Gene: Cdk2 / 42453
• FlyBaseID: FBgn0004107
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: XP_011536034.1
• Gene: CDK2 / 1017
• HGNCID: 1771
• Length: 346
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 193/346 - (55%)
• Similarity: 235/346 - (67%)
• Gaps: 52/346 - (15%)

  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69
            ::|||:.|||||||||:|||||:..||:.||||||||:.|||||||||||||||||.|.|||:|:
Human     1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65

  Fly    70 LFDVVISGNNLYMIFEYLNMDLKKLMDKKKDVFTP-QLIKSYMHQILDAVGFCHTNRILHRDLKP 133
            |.||:.:.|.||::||:|:.||||.||.......| .|||||:.|:|..:.|||::|:|||||||
Human    66 LLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKP 130

  Fly   134 QNLLVDTAGKIKLADFGLARAFNVPMRAYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSE 198
            ||||::|.|.||||||||||||.||:|.||||||||||||||||||.|:|||.||||||||||:|
Human   131 QNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE 195

  Fly   199 M------------------------------------------------IMRRSLFPGDSEIDQL 215
            |                                                :.||:|||||||||||
Human   196 MHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQL 260

  Fly   216 YRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQ--PITEHEAHELIMSMLCYDPNLRISA 278
            :||||||.||||..|||||.:||:|..||:|...:..:  |..:.:...|:..||.||||.||||
Human   261 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 325

  Fly   279 KDALQHAYFRNV-QHVDHVAL 298
            |.||.|.:|::| :.|.|:.|
Human   326 KAALAHPFFQDVTKPVPHLRL 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk2	NP_001163666.1	PLN00009	5..293	CDD:177649	190/339 (56%)
		STKc_CDK1_CdkB_like	8..287	CDD:270829	187/329 (57%)
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	188/330 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	388	1.000	Domainoid score	I796
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74409
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1973
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860