Protein Alignment Oct-TyrR and TAAR8

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_444508.1
• Gene: TAAR8 / 83551
• HGNCID: 14964
• Length: 342
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 115/494 - (23%)
• Similarity: 163/494 - (32%)
• Gaps: 227/494 - (45%)

  Fly   121 VLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLW 185
            :|.:.||:||:.||..:|.|....||.|.|||.||..|.:.|:.|::..::...|.||...|.|.
Human    43 LLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLH 107

  Fly   186 LTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPL-IGWN 249
            ..|||..|.||:|:||.|.:|||..:|||:.||.|.||....:.||..|:|.|..|.... .|.|
Human   108 SCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVN 172

  Fly   250 -DWPDEFTSAT----PCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKL 309
             |..:|..||.    .|::...:|:|:...| .||||..:|.|:|.:||:..:
Human   173 DDGLEELVSALNCVGGCQIIVSQGWVLIDFL-LFFIPTLVMIILYSKIFLIAK------------ 224

  Fly   310 NTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQD 374
                                                                |::|..||    .
Human   225 ----------------------------------------------------QQAIKIET----T 233

  Fly   375 SSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDG 439
            |||.                                        :|||
Human   234 SSKV----------------------------------------ESSS----------------- 241

  Fly   440 GSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQK 504
                                                                             
Human   242 ----------------------------------------------------------------- 241

  Fly   505 KTSGVNQFIEEKQKISLSK-ERRAARTLGIIMGVFVICWLPFFLMYVILPFC---------QTCC 559
                      |..||.::| ||:||:|||:.:..|||.|||:.:..:|..|.         :.||
Human   242 ----------ESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICC 296

  Fly   560 PTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
                      |..|.||.:||:||.:|...:|:|.|.:|
Human   297 ----------WSAYYNSAMNPLIYALFYPWFRKAIKLIL 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	70/178 (39%)
		TM helix 1	111..137	CDD:320188	7/15 (47%)
		TM helix 2	144..170	CDD:320188	11/25 (44%)
		TM helix 3	182..212	CDD:320188	15/29 (52%)
		TM helix 4	224..247	CDD:320188	6/23 (26%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	29/84 (35%)
		TM helix 6	528..550	CDD:410628	10/21 (48%)
		TM helix 7	562..587	CDD:410628	8/24 (33%)
TAAR8	NP_444508.1	7tmA_TAAR6_8_9	32..321	CDD:320439	112/488 (23%)
		TM helix 1	33..59	CDD:320439	7/15 (47%)
		TM helix 2	66..92	CDD:320439	11/25 (44%)
		TM helix 3	104..134	CDD:320439	15/29 (52%)
		TM helix 4	146..169	CDD:320439	6/22 (27%)
		TM helix 5	193..222	CDD:320439	12/29 (41%)
		TM helix 6	250..280	CDD:320439	14/29 (48%)
		TM helix 7	289..314	CDD:320439	10/34 (29%)