Protein Alignment Oct-TyrR and htr2b

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001038208.1
• Gene: htr2b / 751784
• ZFINID: ZDB-GENE-081022-57
• Length: 443
• Species: Danio rerio
• Alignment Length: 510
• Identity: 142/510 - (27%)
• Similarity: 216/510 - (42%)
• Gaps: 172/510 - (33%)

  Fly   106 EWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPF---NV 167
            :|.:...||::.::||.||.|||||||:|...:.|:...|||::|||||||.|.|||:|.   .|
Zfish    11 DWPSHWAALLILLVIVPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTV 75

  Fly   168 AYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISG 232
            .|:  ..|.....||.:||..|||..|:||::||||:||||.||..||.::|.::..:||..|:.
Zfish    76 LYN--STWPLADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIAL 138

  Fly   233 VWLLSLLISSP-PLIG--WNDWPD-EFTSATPCELTSQ--RGYVIYSSLGSFFIPLAIMTIVYIE 291
            |||:|:.|:.| |:.|  :.|.|: .|.....|.|:.:  |.:.:|.||.:||||||||.|:|:.
Zfish   139 VWLISIGIAIPIPIKGLQFFDHPNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIPLAIMMIIYLL 203

  Fly   292 IFVATRRR---LRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQF 353
            .....|::   ||.||....::|:.  ..||..:|:...:..|| |.|           |||.
Zfish   204 TIQVLRKKAYLLRSRAARPSISTVF--QQELSVLASPEKMVISN-GIK-----------RDRT-- 252

  Fly   354 ATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKS 418
                                                                             
Zfish   253 ----------------------------------------------------------------- 252

  Fly   419 QSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSL 483
                                                                             
Zfish   253 ----------------------------------------------------------------- 252

  Fly   484 KLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLM 548
             |.|....||    ...||::.::     |.::...:|:.|:||::.|||:..:||:.|.|||:.
Zfish   253 -LNPVNPITG----DEVPLRRMST-----IGKRSMQNLTNEQRASKVLGIVFMLFVVMWCPFFIT 307

  Fly   549 YVILPFCQTCCP--TNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN 601
            .|....|:.|..  .::..:...|:||::||:||::||:||..:|.||:|.:..|
Zfish   308 NVTSVLCERCNGNLVDQLLDIFQWVGYVSSGINPLVYTLFNRTFRLAFRRYITCN 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	86/192 (45%)
		TM helix 1	111..137	CDD:320188	14/25 (56%)
		TM helix 2	144..170	CDD:320188	16/28 (57%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	10/23 (43%)
		TM helix 5	266..294	CDD:320188	14/29 (48%)
		7tm_GPCRs	<519..594	CDD:475119	28/76 (37%)
		TM helix 6	528..550	CDD:410628	9/21 (43%)
		TM helix 7	562..587	CDD:410628	9/24 (38%)
htr2b	NP_001038208.1	7tm_GPCRs	15..362	CDD:475119	140/504 (28%)
		TM helix 1	17..41	CDD:410628	14/23 (61%)
		TM helix 2	50..72	CDD:410628	15/21 (71%)
		TM helix 3	89..111	CDD:410628	12/21 (57%)
		TM helix 4	134..150	CDD:410628	6/15 (40%)
		TM helix 5	179..202	CDD:410628	13/22 (59%)
		TM helix 6	287..309	CDD:410628	9/21 (43%)
		TM helix 7	323..348	CDD:410628	9/24 (38%)