Protein Alignment Oct-TyrR and hrh2a

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001038803.2
• Gene: hrh2a / 735303
• ZFINID: ZDB-GENE-070531-4
• Length: 369
• Species: Danio rerio
• Alignment Length: 493
• Identity: 120/493 - (24%)
• Similarity: 176/493 - (35%)
• Gaps: 208/493 - (42%)

  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177
            |:.|||:|:||:.|||||.|:|:..:.||.|.|.|||||||.|..:..|||||:..|.:.|.|..
Zfish     8 AVTLSVLILLTVSGNILVCLAVYATRRLRNVTNCFIVSLAVTDFLLGALVLPFSTLYQVTGDWPL 72

  Fly   178 GIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISS 242
            |.|.|.::::.||:.||:|||||.||:||||:|:|.|:.|.......||..:::.:||:|:.:|.
Zfish    73 GAHFCNIYISLDVMLCTASILNLFAISLDRYFAVTAPLRYPMLVLPWRVGAILATIWLVSVGVSF 137

  Fly   243 PPL-IGWNDWP------DEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRL 300
            .|: :|||...      .|...|..|.......|.|..:..:|::||..|...|..:|     |:
Zfish   138 VPIHLGWNTRDLSVQNIREGDHARDCRFELNPTYAIVDAFSTFYLPLLAMCWSYHRVF-----RI 197

  Fly   301 RERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESI 365
             .|.||.::
Zfish   198 -ARMRAKRI-------------------------------------------------------- 205

  Fly   366 SSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQ 430
                                                                             
Zfish   206 ----------------------------------------------------------------- 205

  Fly   431 QLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVA 495
                                       |||..||                        .||.||.
Zfish   206 ---------------------------ISTRRGS------------------------TSSQGVT 219

  Fly   496 AVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCP 560
            .:::                       :|.:|..||.:::|.||:||.|:|..:.|:.......|
Zfish   220 ILTL-----------------------REHKATVTLAVVLGAFVVCWFPYFTFFTIMGIRNEENP 261

  Fly   561 TNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            ....::.:.||||.||.||||:|...|.|:|.|:.:||
Zfish   262 PQTAQSVVLWLGYANSALNPVLYATLNRDFRSAYAKLL 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	76/187 (41%)
		TM helix 1	111..137	CDD:320188	14/23 (61%)
		TM helix 2	144..170	CDD:320188	14/25 (56%)
		TM helix 3	182..212	CDD:320188	17/29 (59%)
		TM helix 4	224..247	CDD:320188	7/23 (30%)
		TM helix 5	266..294	CDD:320188	7/27 (26%)
		7tm_GPCRs	<519..594	CDD:475119	27/74 (36%)
		TM helix 6	528..550	CDD:410628	9/21 (43%)
		TM helix 7	562..587	CDD:410628	11/24 (46%)
hrh2a	NP_001038803.2	7tmA_Histamine_H2R	5..295	CDD:320179	117/487 (24%)
		TM helix 1	6..32	CDD:320179	14/23 (61%)
		TM helix 2	39..66	CDD:320179	15/26 (58%)
		TM helix 3	77..107	CDD:320179	17/29 (59%)
		TM helix 4	119..139	CDD:320179	6/19 (32%)
		TM helix 5	168..198	CDD:320179	9/35 (26%)
		TM helix 6	223..253	CDD:320179	11/52 (21%)
		TM helix 7	263..288	CDD:320179	11/24 (46%)