Protein Alignment Oct-TyrR and adora2aa

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001034904.1
• Gene: adora2aa / 561701
• ZFINID: ZDB-GENE-080723-28
• Length: 442
• Species: Danio rerio
• Alignment Length: 506
• Identity: 105/506 - (20%)
• Similarity: 164/506 - (32%)
• Gaps: 235/506 - (46%)

  Fly   114 LVLSVII-VLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177
            ::|.::| :|:::||:||..:|.....|:.:.|||:|||||||:.|.:|.:||::..|
Zfish    11 MILELLIALLSVLGNVLVCWAVGLNSNLQSITNFFVVSLAVADIAVGVLAIPFSIVIS------- 68

  Fly   178 GIHLCK-----LWLTCDVLCCT-SSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLL 236
             ...|.     |::.|.||..| |||.:|.|||:|||.||..|:.|....|..|...:|:..|:|
Zfish    69 -TGFCANFYGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIKIPLRYNSLVTGQRARGIIAICWVL 132

  Fly   237 SLLISSPPLIGWND--WPDEFTSATP-----C--ELTSQRGYVIYSSLGSFF----IPLAIMTIV 288
            |::|...|::||:.  ..:......|     |  |......|::|.   :||    :||.:|..:
Zfish   133 SVIIGLTPMLGWHKARLQEGHNGTCPPGMMECLFEEVVVMDYMVYF---NFFACVLVPLLLMLAI 194

  Fly   289 YIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQF 353
            |:.||:|.|.:|:                                           |.
Zfish   195 YLRIFMAARHQLK-------------------------------------------CI------- 209

  Fly   354 ATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKS 418
                                 .|||.|
Zfish   210 ---------------------ESKAIP-------------------------------------- 215

  Fly   419 QSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSL 483
                                                                  |
Zfish   216 ------------------------------------------------------C---------- 216

  Fly   484 KLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLM 548
                                          |.|.:.:|.||..||::|.||:|:|.:||||..::
Zfish   217 ------------------------------ELKSRSTLQKEVHAAKSLAIIVGLFAVCWLPLHII 251

  Fly   549 YVILPFCQTC-CPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            .....||..| .|..........|.:.||.:||.||.....::|..|::::
Zfish   252 NCFTLFCPECERPPALIMYLAIILSHANSVVNPFIYAYRIREFRHTFRKIV 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	66/199 (33%)
		TM helix 1	111..137	CDD:320188	8/23 (35%)
		TM helix 2	144..170	CDD:320188	14/25 (56%)
		TM helix 3	182..212	CDD:320188	17/35 (49%)
		TM helix 4	224..247	CDD:320188	7/22 (32%)
		TM helix 5	266..294	CDD:320188	9/31 (29%)
		7tm_GPCRs	<519..594	CDD:475119	26/75 (35%)
		TM helix 6	528..550	CDD:410628	10/21 (48%)
		TM helix 7	562..587	CDD:410628	7/24 (29%)
adora2aa	NP_001034904.1	7tmA_Adenosine_R_A2A	8..298	CDD:320196	104/500 (21%)
		TM helix 1	9..35	CDD:320196	8/23 (35%)
		TM helix 2	42..69	CDD:320196	15/34 (44%)
		TM helix 3	78..108	CDD:320196	16/29 (55%)
		TM helix 4	122..140	CDD:320196	5/17 (29%)
		TM helix 5	172..202	CDD:320196	10/32 (31%)
		TM helix 6	225..255	CDD:320196	13/29 (45%)
		TM helix 7	266..291	CDD:320196	7/24 (29%)