Protein Alignment Oct-TyrR and adora2b

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001034902.1
• Gene: adora2b / 560100
• ZFINID: ZDB-GENE-060511-1
• Length: 351
• Species: Danio rerio
• Alignment Length: 524
• Identity: 116/524 - (22%)
• Similarity: 173/524 - (33%)
• Gaps: 240/524 - (45%)

  Fly   108 EALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSIL 172
            ::|..|:.| ||.||:|.||:||..:|.....|:...|:|:|||||||:.|..|.:||.:..||
Zfish     2 DSLYIAIEL-VIAVLSIAGNVLVCWAVAINSTLKNATNYFLVSLAVADILVGCLAIPFAITISI- 64

  Fly   173 GRWE--FGIHLCKLWLTCDVLCCT-SSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVW 234
            |.|.  :|   | |:|.|.||..| |||.:|.|:|:|||.|:..|:.|.:..|..|...:|:.:|
Zfish    65 GLWSDFYG---C-LFLACFVLVLTQSSIFSLLAVAIDRYLAVKIPLRYRELVTGKRAREIITILW 125

  Fly   235 LLSLLISSPPLIGWN-----------------DWPDEFTSAT----------PC--ELTSQRGYV 270
            :||.:|...|.:|||                 :..|:..:.|          .|  |......|:
Zfish   126 ILSFIIGLIPFVGWNRKDLACSRNKSGSLQTSNSSDDDAAETETGFLQSCYLECFFEKVVDMSYM 190

  Fly   271 IY-SSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSG 334
            :| :..|....||.||..:|.:||...|::||:         |.||
Zfish   191 VYFNFFGCVLPPLLIMLGIYAKIFTVARKQLRQ---------IELK------------------- 227

  Fly   335 SKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSR 399
                       |                 |:|
Zfish   228 -----------C-----------------SVS--------------------------------- 231

  Fly   400 RAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGS 464
                                       :||.|                |.|
Zfish   232 ---------------------------NGENQ----------------HHG-------------- 239

  Fly   465 DPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAAR 529
                                                                   .|.:|.|||:
Zfish   240 -------------------------------------------------------LLQREIRAAK 249

  Fly   530 TLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAF 594
            :|.||:|:|.:||||..::..:..|.......:...|....|.:.||.:||:||.....::|..|
Zfish   250 SLSIIVGLFALCWLPVHILNCLTLFYSELKKPSFIMNIAIILSHANSAVNPIIYAYRIREFRVTF 314

  Fly   595 KRLL 598
            :::|
Zfish   315 RKIL 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	75/216 (35%)
		TM helix 1	111..137	CDD:320188	12/25 (48%)
		TM helix 2	144..170	CDD:320188	13/25 (52%)
		TM helix 3	182..212	CDD:320188	17/30 (57%)
		TM helix 4	224..247	CDD:320188	7/22 (32%)
		TM helix 5	266..294	CDD:320188	9/28 (32%)
		7tm_GPCRs	<519..594	CDD:475119	24/74 (32%)
		TM helix 6	528..550	CDD:410628	10/21 (48%)
		TM helix 7	562..587	CDD:410628	8/24 (33%)
adora2b	NP_001034902.1	7tm_GPCRs	3..314	CDD:475119	114/517 (22%)
		TM helix 1	5..29	CDD:410628	12/24 (50%)
		TM helix 2	38..60	CDD:410628	13/21 (62%)
		TM helix 3	74..96	CDD:410628	11/21 (52%)
		TM helix 4	119..135	CDD:410628	5/15 (33%)
		TM helix 5	188..211	CDD:410628	7/22 (32%)
		TM helix 6	248..270	CDD:410628	10/21 (48%)
		TM helix 7	282..307	CDD:410628	8/24 (33%)