Protein Alignment Oct-TyrR and drd4b

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001012636.1
• Gene: drd4b / 503565
• ZFINID: ZDB-GENE-070508-3
• Length: 382
• Species: Danio rerio
• Alignment Length: 494
• Identity: 143/494 - (28%)
• Similarity: 225/494 - (45%)
• Gaps: 138/494 - (27%)

  Fly   109 ALLT----ALVLSVIIVLTII-GNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVA 168
            ||.|    |||..:::::.|| ||:||.|||:..|.|:...|:||||||||||.:|:||||..|.
Zfish    12 ALFTYNVPALVFGILLIIVIICGNVLVCLSVYKEKALKTTTNYFIVSLAVADLMLAVLVLPLFVY 76

  Fly   169 YSILGR-WEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISG 232
            ....|. |...:.:|...:|.||:.||:||.|||||::||:.|::.|:||.:|....|.::|:|.
Zfish    77 AEFQGGVWSLNVSVCDGLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRKHVDYRQIILLSA 141

  Fly   233 VWLLSLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATR 297
            .|||:|.::||.:.|.|:.|..  ..:.|:| ....||:|||:.|||||..||.::|..:|...
Zfish   142 TWLLALAVASPVIFGINNVPQR--DPSECKL-EDNNYVVYSSVCSFFIPCPIMLMLYFGMFHGL- 202

  Fly   298 RRLRERARANKLNTI-ALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQND 361
            |:..|..:|...|:| |.:|.:...:|.:.|...:...|..|::.      ||.|       |:.
Zfish   203 RKWEETRKAKLRNSIQACRSLQHAAVAAALPPLGALPASLPRVIE------RDLA-------QSS 254

  Fly   362 QESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEP 426
            .|.:...| ||                   |.......:..|..::.:...:.|:|:|
Zfish   255 LEELDDFT-QP-------------------VCPFPPEYKNSTIQTVAYSDIQYGQKTQ------- 292

  Fly   427 HGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSS 491
                                                                             
Zfish   293 ----------------------------------------------------------------- 292

  Fly   492 TGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQ 556
                       :||.:.:|           .:||:|.|.|.:::|||:.||.|||:::.....|:
Zfish   293 -----------RKKRAKIN-----------GRERKAMRVLPVVVGVFLFCWTPFFVVHTTRALCE 335

  Fly   557 TCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFK 595
            :|..::...:.:|||||:||.|||:|||:||.::|:.|:
Zfish   336 SCHISSDLMSTVTWLGYVNSALNPIIYTVFNTEFRKFFR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	82/189 (43%)
		TM helix 1	111..137	CDD:320188	13/30 (43%)
		TM helix 2	144..170	CDD:320188	17/25 (68%)
		TM helix 3	182..212	CDD:320188	16/29 (55%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	13/27 (48%)
		7tm_GPCRs	<519..594	CDD:475119	31/74 (42%)
		TM helix 6	528..550	CDD:410628	10/21 (48%)
		TM helix 7	562..587	CDD:410628	13/24 (54%)
drd4b	NP_001012636.1	7tmA_D4_dopamine_R	20..373	CDD:320434	139/483 (29%)
		TM helix 1	20..45	CDD:320434	12/24 (50%)
		TM helix 2	52..78	CDD:320434	17/25 (68%)
		TM helix 3	91..121	CDD:320434	16/29 (55%)
		TM helix 4	133..156	CDD:320434	9/22 (41%)
		TM helix 5	172..201	CDD:320434	14/28 (50%)
		TM helix 6	301..331	CDD:320434	13/29 (45%)
		TM helix 7	341..366	CDD:320434	13/24 (54%)