Protein Alignment Oct-TyrR and AdoR

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 517
• Identity: 110/517 - (21%)
• Similarity: 177/517 - (34%)
• Gaps: 187/517 - (36%)

  Fly    87 EGAVEELHASILGLQLA---VPEWEALLTALVLSVII-VLTIIGNILVILSVFTYKPLRIVQNFF 147
            ||.:..|||:.......   .|..|..:...|..|:: :::||||:|||:.....:.||...|::
  Fly    15 EGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYY 79

  Fly   148 IVSLAVADLTVALLVLPFNVAYSI-LGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAI 211
            |||||:|||.|..|.:||.:..|: |.|   .:|.|...::..|:.||.||..|.|:::||||||
  Fly    80 IVSLAMADLLVGALGIPFAILASMGLPR---NLHACLFTVSLLVVLCTISIFCLVAVSVDRYWAI 141

  Fly   212 TDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLG 276
            ..|:.|::.......:.:||..|:...::...||.||:...:........|:... .|:::....
  Fly   142 LYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHADVNHNQECLFVEVMDY-NYLVFLYFA 205

  Fly   277 SFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLA 341
            :...|..:|...|..|:....:::|:....|..:.::.:|        |:.|
  Fly   206 TIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASDLSRRS--------SAAV------------- 249

  Fly   342 SWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDS 406
                     .|..||
  Fly   250 ---------VQVTTP-------------------------------------------------- 255

  Fly   407 IKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQ 471
                    ||                             |||:|
  Fly   256 --------GR-----------------------------GGHTG--------------------- 262

  Fly   472 VCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMG 536
                     |.|::      .|.|.                         .::.:|.:.|.||:.
  Fly   263 ---------TMLRV------LGAAR-------------------------KRDVKATQNLSIIVL 287

  Fly   537 VFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            .|:|||:|.:.:..|..||..|....|...|...|.::||.:|||:|.....|:|.|.|.||
  Fly   288 FFMICWIPLYTINCIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLL 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	57/185 (31%)
		TM helix 1	111..137	CDD:320188	9/26 (35%)
		TM helix 2	144..170	CDD:320188	13/25 (52%)
		TM helix 3	182..212	CDD:320188	13/29 (45%)
		TM helix 4	224..247	CDD:320188	5/22 (23%)
		TM helix 5	266..294	CDD:320188	5/27 (19%)
		7tm_GPCRs	<519..594	CDD:475119	24/74 (32%)
		TM helix 6	528..550	CDD:410628	8/21 (38%)
		TM helix 7	562..587	CDD:410628	9/24 (38%)
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	99/484 (20%)
		TM helix 1	43..69	CDD:341316	9/25 (36%)
		TM helix 2	76..103	CDD:341316	13/26 (50%)
		TM helix 3	112..142	CDD:341316	13/29 (45%)
		TM helix 4	156..174	CDD:341316	3/17 (18%)
		TM helix 5	196..225	CDD:341316	5/29 (17%)
		TM helix 6	273..303	CDD:341316	9/29 (31%)
		TM helix 7	313..338	CDD:341316	9/24 (38%)