Protein Alignment Oct-TyrR and Octbeta2R

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 619
• Identity: 169/619 - (27%)
• Similarity: 235/619 - (37%)
• Gaps: 227/619 - (36%)

  Fly    11 NVTT--TVAAAALTAAAAVSTTKSGSGNAARGYTDSDDDAGMGTEAVANIS-GSLVEGLTTVTAA 72
            ::||  .|.|||||.||.:.||     ||.         |..|:.:.:|.| |.:...|.|.|.|
  Fly    58 SLTTLARVTAAALTTAAMLHTT-----NAL---------AATGSSSASNSSTGGIALPLGTATPA 108

  Fly    73 LSTAQADKDSAG------ECEGAVEELHASILGLQLAVPE--------WEALLTALVLSVIIVLT 123
            .....|.:...|      |....:.:.|..    |...|:        |  :..|.|:.:||:..
  Fly   109 THELNATQPFGGSGLNFNESGAGLSDHHHH----QQHNPDEDWLDNIVW--VFKAFVMLLIIIAA 167

  Fly   124 IIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTC 188
            |.||:|||:||...:.||::.|:|:||||:||:.||::.:.||.:..:.|||.|...||.||.:.
  Fly   168 ICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSL 232

  Fly   189 DVLCCTSSILNLCAIALDRYWAITDPINY---AQKRTVGRVLLLISGVWLLSLLISSPPL-IGWN 249
            ||...|:|||:||.|::|||:||..|:.|   ..||.||.:||   ..|:...|:|..|: |||.
  Fly   233 DVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLL---NTWISPALLSFLPIFIGWY 294

  Fly   250 DWPDE----FTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKL- 309
            ..|..    ..:.|.|.....:.|.:.||..||:||..||...|:.||       ||..|..|.
  Fly   295 TTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIF-------REANRQEKQL 352

  Fly   310 -----NTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSET 369
                 |.:.:....::|    |..|.|.|||...|                .:.:.:||
  Fly   353 MMRHGNAMLMHRPSMQP----SGEALSGSGSSKTL----------------TLHEVEQE------ 391

  Fly   370 HQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLP 434
            |.|                              |||
  Fly   392 HTP------------------------------TKD----------------------------- 397

  Fly   435 AGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSV 499
                                                                             
  Fly   398 ----------------------------------------------------------------- 397

  Fly   500 TPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKF 564
                            |..|.:.:|.:||||||||||.|::|||||||.|.:...|:.|...:..
  Fly   398 ----------------KHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIV 446

  Fly   565 KNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            .:.:.|:||.||.|||:||..||.|:|.||:..|
  Fly   447 VSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	77/191 (40%)
		TM helix 1	111..137	CDD:320188	12/25 (48%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	16/29 (55%)
		TM helix 4	224..247	CDD:320188	7/23 (30%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	37/74 (50%)
		TM helix 6	528..550	CDD:410628	17/21 (81%)
		TM helix 7	562..587	CDD:410628	10/24 (42%)
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	136/496 (27%)
		TM helix 1	155..181	CDD:320194	12/25 (48%)
		TM helix 2	188..214	CDD:320194	12/25 (48%)
		TM helix 3	226..256	CDD:320194	16/29 (55%)
		TM helix 4	268..291	CDD:320194	9/25 (36%)
		TM helix 5	315..344	CDD:320194	12/35 (34%)
		TM helix 6	404..434	CDD:320194	20/29 (69%)
		TM helix 7	444..469	CDD:320194	10/24 (42%)