Protein Alignment Oct-TyrR and htr5ab

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001007122.1
• Gene: htr5ab / 368475
• ZFINID: ZDB-GENE-030616-574
• Length: 346
• Species: Danio rerio
• Alignment Length: 491
• Identity: 130/491 - (26%)
• Similarity: 207/491 - (42%)
• Gaps: 181/491 - (36%)

  Fly   109 ALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILG 173
            ::||..:|::::|.|.:.|:||::::...:....|.:..:.|:|::|:.||.||:|.::...:.|
Zfish    30 SVLTLTLLAMLVVATFVWNLLVLVTILRVRTFHRVPHNLVASMAISDVMVAGLVMPLSLVRELYG 94

  Fly   174 -RWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGV-WLL 236
             ||..|..||::|::|||||||:||.|:.||||||||:||..:.|..| |..|:..::.|: |||
Zfish    95 RRWILGRALCQVWISCDVLCCTASIWNVTAIALDRYWSITRHLEYTLK-TRKRISNVMIGLTWLL 158

  Fly   237 SLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLR 301
            |.:||..||.||.:...|.:.|  |:::.:..|.::|:.|:|::||.::..||.:|:.|.:.|:.
Zfish   159 SSVISLSPLFGWGETYSEDSLA--CQVSQEPSYTVFSTFGAFYLPLCVVLFVYWKIYKAAKFRIG 221

  Fly   302 ERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESIS 366
            .|    |.|||                                          |||.:
Zfish   222 SR----KTNTI------------------------------------------TPMAE------- 233

  Fly   367 SETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQ 431
                                     |:.||::.|
Zfish   234 -------------------------VIEVKEAER------------------------------- 242

  Fly   432 LLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAA 496
                                                                   .||.:..|..
Zfish   243 -------------------------------------------------------QPQMAFTVRH 252

  Fly   497 VSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPT 561
            .:|:           |..:.:.....||||||..:||::||||:||:||||..:|:|.| :|...
Zfish   253 ATVS-----------FQTDGETWREQKERRAALMVGILIGVFVLCWIPFFLAELIIPLC-SCDIP 305

  Fly   562 NKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRL 597
            ..:|:...||||.||..||:|||.||.:|..||:.|
Zfish   306 PVWKSVFLWLGYSNSFFNPLIYTAFNKNYNNAFRNL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	71/185 (38%)
		TM helix 1	111..137	CDD:320188	8/25 (32%)
		TM helix 2	144..170	CDD:320188	8/25 (32%)
		TM helix 3	182..212	CDD:320188	20/29 (69%)
		TM helix 4	224..247	CDD:320188	10/23 (43%)
		TM helix 5	266..294	CDD:320188	9/27 (33%)
		7tm_GPCRs	<519..594	CDD:475119	37/74 (50%)
		TM helix 6	528..550	CDD:410628	13/21 (62%)
		TM helix 7	562..587	CDD:410628	12/24 (50%)
htr5ab	NP_001007122.1	7tmA_5-HT5	31..338	CDD:320451	127/485 (26%)
		TM helix 1	32..58	CDD:320451	8/25 (32%)
		TM helix 2	65..91	CDD:320451	8/25 (32%)
		TM helix 3	104..134	CDD:320451	20/29 (69%)
		TM helix 4	146..167	CDD:320451	8/20 (40%)
		TM helix 5	186..215	CDD:320451	9/28 (32%)
		TM helix 6	267..297	CDD:320451	18/29 (62%)
		TM helix 7	306..331	CDD:320451	12/24 (50%)