DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Oct-TyrR and HTR2A

DIOPT Version :10

Sequence 1:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_000612.1 Gene:HTR2A / 3356 HGNCID:5293 Length:471 Species:Homo sapiens


Alignment Length:530 Identity:138/530 - (26%)
Similarity:215/530 - (40%) Gaps:186/530 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 TAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKP 139
            |..::..:...|||.:.....|:|.||  ...|.|||||    |:|:|||.||||||::|...|.
Human    46 TVDSENRTNLSCEGCLSPSCLSLLHLQ--EKNWSALLTA----VVIILTIAGNILVIMAVSLEKK 104

  Fly   140 LRIVQNFFIVSLAVADLTVALLVLPFNVAYSILG-RWEFGIHLCKLWLTCDVLCCTSSILNLCAI 203
            |:...|:|::|||:||:.:..||:|.::...:.| ||.....||.:|:..|||..|:||::||||
Human   105 LQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAI 169

  Fly   204 ALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSP-PLIGWNDWPDEFTSATPCELTSQR 267
            :||||.||.:||::::..:..:..|.|..||.:|:.||.| |:.|..|....|...: | |.:..
Human   170 SLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGS-C-LLADD 232

  Fly   268 GYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASN 332
            .:|:..|..||||||.||.|.|.                     :.:||.:.|     :.:..|:
Human   233 NFVLIGSFVSFFIPLTIMVITYF---------------------LTIKSLQKE-----ATLCVSD 271

  Fly   333 SGSKSRLLA-SWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVK 396
            .|::::|.: |:|                .|.|:|||                            
Human   272 LGTRAKLASFSFL----------------PQSSLSSE---------------------------- 292

  Fly   397 KSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTE 461
                               :..|.|...||                   |.::|           
Human   293 -------------------KLFQRSIHREP-------------------GSYTG----------- 308

  Fly   462 SGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERR 526
                                                                 .:...|:|.|::
Human   309 -----------------------------------------------------RRTMQSISNEQK 320

  Fly   527 AARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTN---KFKNFITWLGYINSGLNPVIYTIFNL 588
            |.:.|||:..:||:.|.|||:..::...|:..|..:   ...|...|:||::|.:||::||:||.
Human   321 ACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNK 385

  Fly   589 DYRRAFKRLL 598
            .||.||.|.:
Human   386 TYRSAFSRYI 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 78/185 (42%)
TM helix 1 111..137 CDD:320188 15/25 (60%)
TM helix 2 144..170 CDD:320188 10/25 (40%)
TM helix 3 182..212 CDD:320188 17/29 (59%)
TM helix 4 224..247 CDD:320188 9/23 (39%)
TM helix 5 266..294 CDD:320188 12/27 (44%)
7tm_GPCRs <519..594 CDD:475119 28/77 (36%)
TM helix 6 528..550 CDD:410628 9/21 (43%)
TM helix 7 562..587 CDD:410628 9/27 (33%)
HTR2ANP_000612.1 7tmA_5-HT2A 75..391 CDD:341345 127/493 (26%)
TM helix 1 76..102 CDD:341345 18/29 (62%)
TM helix 2 109..135 CDD:341345 10/25 (40%)
TM helix 3 148..178 CDD:341345 17/29 (59%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 172..174 1/1 (100%)
TM helix 4 190..213 CDD:341345 9/22 (41%)
TM helix 5 231..260 CDD:341345 12/49 (24%)
TM helix 6 316..346 CDD:341345 12/29 (41%)
TM helix 7 359..384 CDD:341345 9/24 (38%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 376..380 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..471
PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405 469..471
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.