Protein Alignment Oct-TyrR and HTR1F

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_000857.1
• Gene: HTR1F / 3355
• HGNCID: 5292
• Length: 366
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 149/501 - (29%)
• Similarity: 221/501 - (44%)
• Gaps: 174/501 - (34%)

  Fly   110 LLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGR 174
            :|.:|.||.:.::|...|.|||.::...:.|....|:.|.||||.|..||:||:||::.|.:...
Human    24 ILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRES 88

  Fly   175 WEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLL 239
            |..|..:|.:||:.|:.|||.|||:|.|||||||.||||.:.||:|||.....::|:.||::|:.
Human    89 WIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVF 153

  Fly   240 ISSPPLIGWNDWPDEFTSATPCELTSQRGYV---IYSSLGSFFIPLAIMTIVYIEIFVATRRRLR 301
            ||.|||.    |..:.||... |...:..::   |||:.|:|:||||::.|:|.:|:
Human   154 ISMPPLF----WRHQGTSRDD-ECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIY-------- 205

  Fly   302 ERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESIS 366
                                                                             
Human   206 ----------------------------------------------------------------- 205

  Fly   367 SETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQ 431
                                            |.|||   :.|       |.|:|...:.....|
Human   206 --------------------------------RAAKT---LYH-------KRQASRIAKEEVNGQ 228

  Fly   432 LLPAGGDGGSCQPGGGHSGGGKSDAEIST-----ESGSDPKGCIQVCVTQADEQTSLKLTPPQSS 491
            :|...|:              ||...:||     :|.|||.       |..|:..|
Human   229 VLLESGE--------------KSTKSVSTSYVLEKSLSDPS-------TDFDKIHS--------- 263

  Fly   492 TGVAAVSVTPLQKKTSGVNQFIEEK----QKISLSKERRAARTLGIIMGVFVICWLPFFLMYVIL 552
                  :|..|:      ::|..||    ||||.::||:||.|||:|:|.|||||||||:..:::
Human   264 ------TVRSLR------SEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVV 316

  Fly   553 PFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            ..|..|..:.:..||:.||||:||.:||:||||||.|:::||::|:
Human   317 NVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLV 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	78/186 (42%)
		TM helix 1	111..137	CDD:320188	9/25 (36%)
		TM helix 2	144..170	CDD:320188	13/25 (52%)
		TM helix 3	182..212	CDD:320188	19/29 (66%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	12/30 (40%)
		7tm_GPCRs	<519..594	CDD:475119	39/74 (53%)
		TM helix 6	528..550	CDD:410628	15/21 (71%)
		TM helix 7	562..587	CDD:410628	14/24 (58%)
HTR1F	NP_000857.1	7tmA_5-HT1F	24..359	CDD:320456	147/496 (30%)
		TM helix 1	25..51	CDD:320456	9/25 (36%)
		TM helix 2	58..84	CDD:320456	13/25 (52%)
		TM helix 3	96..126	CDD:320456	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	8/21 (38%)
		TM helix 5	178..207	CDD:320456	12/133 (9%)
		TM helix 6	286..316	CDD:320456	18/29 (62%)
		TM helix 7	326..351	CDD:320456	14/24 (58%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)