Protein Alignment Oct-TyrR and HTR1A

DIOPT Version :9

• Sequence 1: NP_001163494.1
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_000515.2
• Gene: HTR1A / 3350
• HGNCID: 5286
• Length: 422
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 164/492 - (33%)
• Similarity: 239/492 - (48%)
• Gaps: 116/492 - (23%)

  Fly   110 LLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGR 174
            ::|:|:|..:|...::||..|:.::...:.|:.|.|:.|.||||.||.|::||||....|.:|.:
Human    37 VITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK 101

  Fly   175 WEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLL 239
            |..|...|.|::..||||||||||:||||||||||||||||:|..|||..|...|||..||:..|
Human   102 WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFL 166

  Fly   240 ISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERA 304
            ||.||::||.. |::.:....|.::...||.|||:.|:|:|||.:|.::|..||.|.|.|:|:
Human   167 ISIPPMLGWRT-PEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK-- 228

  Fly   305 RANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSET 369
                    .:|..|             .:|:.:|..||
Human   229 --------TVKKVE-------------KTGADTRHGAS--------------------------- 245

  Fly   370 HQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLP 434
              |....|...:|.|..:...:.|..|                .||      :.|.....:|
Human   246 --PAPQPKKSVNGESGSRNWRLGVESK----------------AGG------ALCANGAVRQ--- 283

  Fly   435 AGGDGGSCQPGGGHS-GGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVS 498
             |.||.:.:....|. |..|....:.:|:|..|  |......:.:|:.:
Human   284 -GDDGAALEVIEVHRVGNSKEHLPLPSEAGPTP--CAPASFERKNERNA---------------- 329

  Fly   499 VTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCC--PT 561
                           |.|:|::|::||:..:|||||||.|::||||||::.::||||::.|  ||
Human   330 ---------------EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPT 379

  Fly   562 NKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
             .....|.||||.||.||||||..||.|::.|||:::
Human   380 -LLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	66/130 (51%)
		7tm_1	126..>293	CDD:278431	81/166 (49%)
HTR1A	NP_000515.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		7tm_4	48..>169	CDD:304433	62/120 (52%)
		7tm_1	53..400	CDD:278431	152/459 (33%)
		Agonist binding. /evidence=ECO:0000250	112..121		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	133..135		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..262		8/55 (15%)
		Agonist binding. /evidence=ECO:0000250	358..362		3/3 (100%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	396..400		3/3 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCYC
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104614
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710