Protein Alignment Oct-TyrR and Octalpha2R

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_061501849.1
• Gene: Octalpha2R / 3289716
• VectorBaseID: AGAMI1_006243
• Length: 636
• Species: Anopheles gambiae
• Alignment Length: 674
• Identity: 201/674 - (29%)
• Similarity: 298/674 - (44%)
• Gaps: 159/674 - (23%)

  Fly    11 NVTTTVAAAALTAAAAVSTTKSGSGNAARGYTDSDDDAGMGT-EAVANISGSLVEGLTTVTAALS 74
            |.:..|||||..||||.:...:|.|..|         ||:|. |.:..:.|:...|.|
Mosquito    34 NDSLAVAAAAAAAAAAAAGGVAGPGGTA---------AGVGPGENLTILHGAYPSGYT------- 82

  Fly    75 TAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKP 139
                                         :|  ..::.::::::::::.::||:|||:::.|.|.
Mosquito    83 -----------------------------LP--HIIIASIIVTILMIVIVVGNMLVIIAIATEKT 116

  Fly   140 LRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIA 204
            |:.:||:||.||||||..:.|:::||::|..::|.|.||...|.:....|||.|||||:|||.|:
Mosquito   117 LKNIQNWFIASLAVADFFLGLVIMPFSLANELMGYWIFGNWWCDVHSAMDVLLCTSSIMNLCLIS 181

  Fly   205 LDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWN-DWPDEFTSATPCELTSQRG 268
            |||||:||..|.|.:.||..|...:|:.||::|.|:..|||:||. ..|:.......|:|:...|
Mosquito   182 LDRYWSITKAIEYLKSRTPARAAFMIAAVWIMSALVCIPPLLGWKAQRPEGHVELPQCQLSQDIG 246

  Fly   269 YVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKL------NTIALKSTELEPMANSSP 327
            ||:||:||||:||..||..|||.|:.|.:.|.|...|...|      :|...::....||. |.|
Mosquito   247 YVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIRKKPLKPPSEQDTSFTRNAGTVPMP-SLP 310

  Fly   328 VAASNSGSKSRLLA---------SWLCCGRDRAQFAT------------PMIQND---QESISSE 368
            .|:||:...:...|         |....|....|.||            |::..|   ..|.|..
Mosquito   311 SASSNNNQSAAAAAHHQQHPVQLSSGAQGGGSTQIATIEPPPRGTPMPIPVVTCDFASDMSTSEA 375

  Fly   369 THQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGE---- 429
            ....||.     ||...|      |.::.....|.....:.|::..|..:..::| ||...
Mosquito   376 ATAEQDQ-----HGPISP------VALEPKDTLKVTQPAQQGRSTNGITAAGAAT-EPVASPSSA 428

  Fly   430 ----------------QQLLPAGGDGG--------------SCQP-------------------G 445
                            .:..|:..|.|              .|||                   |
Mosquito   429 AARSRALSVGIDTDMVSEFDPSSSDSGVISRCAVVKPLKFRLCQPIFGKGKAKARQANAKAAGHG 493

  Fly   446 GGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVN 510
            |.|:|.|.:            ..|.|..:.....|.::........|..|...:.|.........
Mosquito   494 GAHAGRGNA------------PNCTQPMLAAPGGQQAISQLIAAKQTDSACSELEPALPPKPKPR 546

  Fly   511 QFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTC-CPTNKFKNFITWLGYI 574
            ...:||::|:..||:||...||:|||.|:.||||||.:|:::|.|..| .|.:.| :...||||:
Mosquito   547 DPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPVCPDCHIPDSAF-SLAFWLGYM 610

  Fly   575 NSGLNPVIYTIFNLDYRRAFKRLL 598
            ||.|||.||||||.|:||||:|:|
Mosquito   611 NSALNPAIYTIFNKDFRRAFRRIL 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	81/184 (44%)
		TM helix 1	111..137	CDD:320188	5/25 (20%)
		TM helix 2	144..170	CDD:320188	14/25 (56%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	17/27 (63%)
		7tm_GPCRs	<519..594	CDD:475119	41/75 (55%)
		TM helix 6	528..550	CDD:410628	12/21 (57%)
		TM helix 7	562..587	CDD:410628	14/24 (58%)
Octalpha2R	XP_061501849.1	None