Protein Alignment Oct-TyrR and TAAR6

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_778237.1
• Gene: TAAR6 / 319100
• HGNCID: 20978
• Length: 345
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 118/524 - (22%)
• Similarity: 178/524 - (33%)
• Gaps: 227/524 - (43%)

  Fly    89 AVEELHASILGLQLAVP--EWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSL 151
            ||:..:|::.|..:.:|  ....::..:|.....||.:.||:||::|:..:|.|....||.:.||
Human    10 AVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLVASL 74

  Fly   152 AVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPIN 216
            |.||..|.:.|:||::..::...|.||...|.....|||..|.||:.:||.|::|||.|:|||:.
Human    75 ACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIAVTDPLV 139

  Fly   217 YAQKRTVGRVLLLISGVWLLSLLISSPPLI------GWNDWPDEFTSATPCELTSQRGYVIYSSL 275
            |..|.||....:.||..|:|.|:.|.....      |..:..|.......|:....:.:|:...|
Human   140 YPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGLEELSDALNCIGGCQTVVNQNWVLTDFL 204

  Fly   276 GSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLL 340
             |||||..||.|:|..||:..||      :|.|:                     .|:|||:
Human   205 -SFFIPTFIMIILYGNIFLVARR------QAKKI---------------------ENTGSKT--- 238

  Fly   341 ASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKD 405
                                  || |||::                          |:|.|:
Human   239 ----------------------ES-SSESY--------------------------KARVAR--- 251

  Fly   406 SIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCI 470
                                                                             
Human   252 ----------------------------------------------------------------- 251

  Fly   471 QVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIM 535
                                                                :||:||:|||:.:
Human   252 ----------------------------------------------------RERKAAKTLGVTV 264

  Fly   536 GVFVICWLPFFL-------MYVILPFC--QTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYR 591
            ..|:|.|||:.:       |..|.|.|  :.||          |..|.||.:||:||.:|...:|
Human   265 VAFMISWLPYSIDSLIDAFMGFITPACIYEICC----------WCAYYNSAMNPLIYALFYPWFR 319

  Fly   592 RAFK 595
            :|.|
Human   320 KAIK 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	66/189 (35%)
		TM helix 1	111..137	CDD:320188	8/25 (32%)
		TM helix 2	144..170	CDD:320188	11/25 (44%)
		TM helix 3	182..212	CDD:320188	14/29 (48%)
		TM helix 4	224..247	CDD:320188	6/28 (21%)
		TM helix 5	266..294	CDD:320188	12/27 (44%)
		7tm_GPCRs	<519..594	CDD:475119	28/83 (34%)
		TM helix 6	528..550	CDD:410628	10/28 (36%)
		TM helix 7	562..587	CDD:410628	8/24 (33%)
TAAR6	NP_778237.1	7tmA_TAAR6_8_9	33..322	CDD:320439	111/498 (22%)
		TM helix 1	34..60	CDD:320439	8/25 (32%)
		TM helix 2	67..93	CDD:320439	11/25 (44%)
		TM helix 3	105..135	CDD:320439	14/29 (48%)
		TM helix 4	147..170	CDD:320439	6/22 (27%)
		TM helix 5	194..223	CDD:320439	13/29 (45%)
		TM helix 6	251..281	CDD:320439	12/149 (8%)
		TM helix 7	290..315	CDD:320439	11/34 (32%)