Protein Alignment Oct-TyrR and drd2a

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_898891.1
• Gene: drd2a / 282557
• ZFINID: ZDB-GENE-021119-2
• Length: 448
• Species: Danio rerio
• Alignment Length: 494
• Identity: 155/494 - (31%)
• Similarity: 244/494 - (49%)
• Gaps: 91/494 - (18%)

  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177
            |::|:::|.:.:.||:||.::|...|.|:...|:.|||||||||.||.||:|:.|...::|.|.|
Zfish    36 AMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRF 100

  Fly   178 GIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPI----NYAQKRTVGRVLLLISGVWLLSL 238
            ....|.:::|.||:.||:||||||||::|||.|:..|:    .|:.||   ||.::||.||:||.
Zfish   101 STIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKR---RVTVMISVVWILSF 162

  Fly   239 LISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRER 303
            .||.|.|.|.|   :..|......:.:...:|:|||:.||::|..|..:||::|:|..|:|   |
Zfish   163 AISCPLLFGLN---NTVTHDDALCVIANPAFVVYSSIVSFYVPFIITLLVYVQIYVVLRKR---R 221

  Fly   304 ARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSE 368
            .|.|...|..:...::     ||.:..              |...|..:..|.:::       |.
Zfish   222 KRVNTKRTCPVTDMDM-----SSTIKK--------------CTHPDDVKLCTVIVK-------SS 260

  Fly   369 THQPQDSSKA----GPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGE 429
            .:.|.::...    ....|.|..|...:.....||:.|...|       ||.:..|........|
Zfish   261 GNCPVNNKNVIFIKEVVNNGDDIQMDEITNRNPSRQRKQDQS-------GGSQQNSRLVNSNLRE 318

  Fly   430 QQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGV 494
            ..:.|...:.|.           |.:...:|.|           :|:..:...::::|    ||.
Zfish   319 TDISPPSPEAGV-----------KPERNGNTSS-----------ITKGAKAFEIQVSP----TGK 357

  Fly   495 AAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCC 559
            ...||..|.|:            |||..||::|.:.|.|::|||:|||||||:.:::..:||.
Zfish   358 TQTSVKTLNKR------------KISQQKEKKATQMLAIVLGVFIICWLPFFITHIVNTYCQV-- 408

  Fly   560 PTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            |...:..| |||||:||.:||:|||.||:::|:||.::|
Zfish   409 PPELYTAF-TWLGYVNSAVNPIIYTTFNIEFRKAFIKIL 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	77/184 (42%)
		TM helix 1	111..137	CDD:320188	8/23 (35%)
		TM helix 2	144..170	CDD:320188	16/25 (64%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	12/22 (55%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	36/74 (49%)
		TM helix 6	528..550	CDD:410628	12/21 (57%)
		TM helix 7	562..587	CDD:410628	13/24 (54%)
drd2a	NP_898891.1	7tmA_D2-like_dopamine_R	33..442	CDD:320181	152/488 (31%)
		TM helix 1	34..60	CDD:320181	8/23 (35%)
		TM helix 2	67..93	CDD:320181	16/25 (64%)
		TM helix 3	105..135	CDD:320181	18/29 (62%)
		TM helix 4	148..171	CDD:320181	13/25 (52%)
		TM helix 5	187..216	CDD:320181	11/28 (39%)
		TM helix 6	218..403	CDD:320181	55/258 (21%)
		TM helix 7	410..435	CDD:320181	13/25 (52%)