Protein Alignment Oct-TyrR and Htr4

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_036985.2
• Gene: Htr4 / 25324
• RGDID: 2850
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 530
• Identity: 124/530 - (23%)
• Similarity: 189/530 - (35%)
• Gaps: 224/530 - (42%)

  Fly    82 SAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLR-IVQN 145
            |:.|..|:||::               .|||  ..:::|::.|:||:||:::|...:.|| |..|
  Rat     9 SSNEGFGSVEKV---------------VLLT--FFAMVILMAILGNLLVMVAVCRDRQLRKIKTN 56

  Fly   146 FFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWA 210
            :||||||.|||.|::||:||.....:...|.:|...|.:..:.|||..|:||.:||.|:||||:|
  Rat    57 YFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

  Fly   211 I-TDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLI-GWNDWP----------DEFTSATPCEL 263
            | ..|:.|..|.|..|:.|::.|.|::.:.||..|:: |||:..          :..:::|.|..
  Rat   122 ICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVF 186

  Fly   264 TSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPV 328
            ...:.|.|..|:.:|:||..:|.:.|..|:|.
  Rat   187 MVNKPYAITCSVVAFYIPFLLMVLAYYRIYVT--------------------------------- 218

  Fly   329 AASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVV 393
                              .::.||                  |.|...:||....|.||
  Rat   219 ------------------AKEHAQ------------------QIQMLQRAGATSESRPQ------ 241

  Fly   394 LVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEI 458
                                         |.:.|...:
  Rat   242 -----------------------------TADQHSTHR--------------------------- 250

  Fly   459 STESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSK 523
                                                                          :..
  Rat   251 --------------------------------------------------------------MRT 253

  Fly   524 ERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNL 588
            |.:||:||.:|||.|..||.|||:..::.||.....|...:..|: |||||||||||.:|...|.
  Rat   254 ETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFL-WLGYINSGLNPFLYAFLNK 317

  Fly   589 DYRRAFKRLL 598
            .:||||..:|
  Rat   318 SFRRAFLIIL 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	71/196 (36%)
		TM helix 1	111..137	CDD:320188	9/25 (36%)
		TM helix 2	144..170	CDD:320188	15/25 (60%)
		TM helix 3	182..212	CDD:320188	16/30 (53%)
		TM helix 4	224..247	CDD:320188	7/23 (30%)
		TM helix 5	266..294	CDD:320188	9/27 (33%)
		7tm_GPCRs	<519..594	CDD:475119	33/74 (45%)
		TM helix 6	528..550	CDD:410628	12/21 (57%)
		TM helix 7	562..587	CDD:410628	13/24 (54%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	116/513 (23%)
		TM helix 1	21..47	CDD:320184	10/27 (37%)
		TM helix 2	55..81	CDD:320184	15/25 (60%)
		TM helix 3	93..123	CDD:320184	15/29 (52%)
		TM helix 4	136..159	CDD:320184	7/22 (32%)
		TM helix 5	189..218	CDD:320184	9/28 (32%)
		TM helix 6	252..282	CDD:320184	14/29 (48%)
		TM helix 7	291..316	CDD:320184	13/25 (52%)