DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oct-TyrR and Htr1d

DIOPT Version :9

Sequence 1:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_036984.1	Gene:	Htr1d / 25323	RGDID:	2847	Length:	374	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	158/529 - (29%)
Similarity:	230/529 - (43%)	Gaps:	186/529 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 EGAVEELHASILGLQLAVPEWE-ALLTAL------VLSVIIVLTIIGNILVILSVFTYKPLRIVQ 144
            ||..:|  ||...|. |...|: .:|.||      |||:|.:.|::.|..|:.::...|.|....
  Rat     9 EGLPQE--ASNRSLN-ATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPA 70

  Fly   145 NFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYW 209
            |:.|.|||..||.|::||:|.::||:....|.||..||.:|::.|:.|||:|||:||.|||||||
  Rat    71 NYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYW 135

  Fly   210 AITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATPCE-------LTSQR 267
            ||||.:.|:::||.|....:|:.||.:|:.||.|||. |.       .||..|       .|||.
  Rat   136 AITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLF-WR-------QATAHEEMSDCLVNTSQI 192

  Fly   268 GYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASN 332
            .|.|||:.|:|:||..::.|:|..|:||.|.|:        ||..:|.....    .::.:...:
  Rat   193 SYTIYSTCGAFYIPSILLIILYGRIYVAARSRI--------LNPPSLYGKRF----TTAQLITGS 245

  Fly   333 SGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKK 397
            :||.       ||                  |::...|
  Rat   246 AGSS-------LC------------------SLNPSLH--------------------------- 258

  Fly   398 SRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTES 462
                                       |.|                                |.:
  Rat   259 ---------------------------ESH--------------------------------THT 264

  Fly   463 GSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRA 527
            ...|....||.:..||.                                 |.|:::||.::||:|
  Rat   265 VGSPLFFNQVKIKLADS---------------------------------ILERKRISAARERKA 296

  Fly   528 ARTLGIIMGVFVICWLPFFLMYVILPFCQTCC---PTNKFKNFITWLGYINSGLNPVIYTIFNLD 589
            .:|||||:|.|:|||||||::.::||.|:..|   |.  ..:|.|||||:||.:||||||:||.|
  Rat   297 TKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPVIYTVFNED 359

  Fly   590 YRRAFKRLL 598
            :|:||:|::
  Rat   360 FRQAFQRVV 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	60/136 (44%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	73/173 (42%)
Htr1d	NP_036984.1	7tmA_5-HT1B_1D	32..364	CDD:320455	146/497 (29%)
		TM helix 1	38..62	CDD:320455	7/23 (30%)
		TM helix 2	71..93	CDD:320455	11/21 (52%)
		TM helix 3	109..131	CDD:320455	11/21 (52%)
		Agonist binding. /evidence=ECO:0000250	111..120		3/8 (38%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	132..134		1/1 (100%)
		TM helix 4	154..170	CDD:320455	6/15 (40%)
		TM helix 5	192..215	CDD:320455	9/22 (41%)
		TM helix 6	297..319	CDD:320455	14/21 (67%)
		Agonist binding. /evidence=ECO:0000250	311..315		3/3 (100%)
		TM helix 7	332..357	CDD:320455	15/26 (58%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	349..353		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20240
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910