Protein Alignment Oct-TyrR and Htr1b

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_071561.1
• Gene: Htr1b / 25075
• RGDID: 2846
• Length: 386
• Species: Rattus norvegicus
• Alignment Length: 499
• Identity: 147/499 - (29%)
• Similarity: 224/499 - (44%)
• Gaps: 160/499 - (32%)

  Fly   102 LAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFN 166
            :|:| |:.||.|| |::|.:.|.:.|..||.:|:..:.|....|:.|.||||.||.|::||:|.:
  Rat    40 IALP-WKVLLVAL-LALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIS 102

  Fly   167 VAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLIS 231
            ..|::.|||..|..:|..||:.|:.|||:||::||.|||||||||||.::|:.|||..|..::|.
  Rat   103 TMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIV 167

  Fly   232 GVWLLSLLISSPPLIGWNDWPDEFTSATPCEL-TSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVA 295
            .||:.|:.||.||.. |.....| .....|.: |....|.:||::|:|::|..::..:|..|:|.
  Rat   168 LVWVFSISISLPPFF-WRQAKAE-EEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVE 230

  Fly   296 TRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQN 360
            .|.|:             ||.|             .|...| ||         .|||    :|.:
  Rat   231 ARSRI-------------LKQT-------------PNKTGK-RL---------TRAQ----LITD 255

  Fly   361 DQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCE 425
            ...|.||.|                                                  |.::..
  Rat   256 SPGSTSSVT--------------------------------------------------SINSRV 270

  Fly   426 PHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQS 490
            |                              |:.:||||      .|.|.|...:
  Rat   271 P------------------------------EVPSESGS------PVYVNQVKVR---------- 289

  Fly   491 STGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFC 555
                              |:..:.||:|:..::||:|.:|||||:|.|::||||||::.:::|.|
  Rat   290 ------------------VSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIC 336

  Fly   556 QTCCPTN-KFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            :..|..: ...:|..||||:||.:||:|||:.|.|:::||.:|:
  Rat   337 KDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLI 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	76/184 (41%)
		TM helix 1	111..137	CDD:320188	10/25 (40%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	19/29 (66%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	8/27 (30%)
		7tm_GPCRs	<519..594	CDD:475119	33/75 (44%)
		TM helix 6	528..550	CDD:410628	13/21 (62%)
		TM helix 7	562..587	CDD:410628	12/25 (48%)
Htr1b	NP_071561.1	7tmA_5-HT1B_1D	42..376	CDD:320455	143/491 (29%)
		TM helix 1	47..73	CDD:320455	11/26 (42%)
		TM helix 2	80..106	CDD:320455	12/25 (48%)
		TM helix 3	118..148	CDD:320455	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	142..144		1/1 (100%)
		TM helix 4	160..183	CDD:320455	9/23 (39%)
		TM helix 5	201..230	CDD:320455	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..276		7/100 (7%)
		TM helix 6	303..333	CDD:320455	16/29 (55%)
		TM helix 7	344..369	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	361..365		2/3 (67%)