DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oct-TyrR and Adra2c

DIOPT Version :9

Sequence 1:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_612515.2	Gene:	Adra2c / 24175	RGDID:	2058	Length:	458	Species:	Rattus norvegicus

Alignment Length:	608	Identity:	187/608 - (30%)
Similarity:	273/608 - (44%)	Gaps:	185/608 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VAAAALTAAAAVSTTKSGSGNAARGYTDSDDDAG-MGTEAVANISGSLVEGLTTVTAALSTAQAD 79
            :|:.||.||.|.:..:..:|:          ||| .|:...||.||:                 |
  Rat     1 MASPALAAALAAAAAEGPNGS----------DAGEWGSGGGANASGT-----------------D 38

  Fly    80 ------KDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYK 138
                  :.|||           ::.||            |.|:..:||.|::||:||:::|.|.:
  Rat    39 WGPPPGQYSAG-----------AVAGL------------AAVVGFLIVFTVVGNVLVVIAVLTSR 80

  Fly   139 PLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAI 203
            .||..||.|:||||.||:.||.||:||::|..::..|.||...|.::|..|||.|||||::||||
  Rat    81 ALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAI 145

  Fly   204 ALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATP-CELTSQR 267
            :|||||::|..:.|..|||..||...|..|||:|.:||.|||:.:...||  .:|.| |.|..:.
  Rat   146 SLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPD--GAAYPQCGLNDET 208

  Fly   268 GYVIYSSLGSFFIPLAIMTIVYIEIF-VATRRRLRERARANKLNTI----ALKSTELEPMANSSP 327
            .|::.|.:||||.|..||.:||..|: ||   :||.|..:.|....    |..:||     |...
  Rat   209 WYILSSCIGSFFAPCLIMGLVYARIYRVA---KLRTRTLSEKRGPAGPDGASPTTE-----NGLG 265

  Fly   328 VAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVV 392
            .||..:|.          |...|.:.                 :|.:||.|
  Rat   266 KAAGENGH----------CAPPRTEV-----------------EPDESSAA-------------- 289

  Fly   393 VLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQ-PGGGHSGGGKSDA 456
                  .|.:.:.:::    ||||:.:.              |.||.||.. ||.|
  Rat   290 ------ERRRRRGALR----RGGRRREG--------------AEGDTGSADGPGPG--------- 321

  Fly   457 EISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEE------ 515
             ::.|.|:               :|:.:...|......|:         :..|..|:..
  Rat   322 -LAAEQGA---------------RTASRSPGPGGRLSRAS---------SRSVEFFLSRRRRARS 361

  Fly   516 ---KQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCC--PTNKFKNFITWLGYIN 575
               ::|::.::|:|....|.::|||||:||.|||..|.:...|:..|  |...|| |..|:||.|
  Rat   362 SVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFK-FFFWIGYCN 425

  Fly   576 SGLNPVIYTIFNLDYRRAFKRLL 598
            |.|||||||:||.|:||:||.:|
  Rat   426 SSLNPVIYTVFNQDFRRSFKHIL 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	65/130 (50%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	80/167 (48%)
Adra2c	NP_612515.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..343		31/192 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020