Protein Alignment Oct-TyrR and Taar8a

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001010830.1
• Gene: Taar8a / 215859
• MGIID: 2685076
• Length: 344
• Species: Mus musculus
• Alignment Length: 493
• Identity: 114/493 - (23%)
• Similarity: 167/493 - (33%)
• Gaps: 223/493 - (45%)

  Fly   121 VLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLW 185
            ||.:.||:||::||..:|.|....||.|.|||.||..|.:.|:||::..||...|.||...|.|.
Mouse    43 VLAVCGNLLVVISVLHFKQLHSPANFLIASLASADFLVGISVMPFSMVRSIESCWYFGDAFCSLH 107

  Fly   186 LTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLI---- 246
            ..|||..|.||:|:||.|::|||.|:|||:.|..|.||....:.||..|:|.|:.||....
Mouse   108 SCCDVAFCYSSVLHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISISWILPLVYSSAVFYTGIS 172

  Fly   247 --GWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKL 309
              |.............|::...:.:|:.|.| .||||..:|.|:|.:||:..::      :|.|:
Mouse   173 AKGIESLVSALNCVGGCQIVINQDFVLISFL-LFFIPTLVMIILYSKIFLVAKQ------QAVKI 230

  Fly   310 NTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQD 374
            .|                   |.||::.                         || |||:|
Mouse   231 ET-------------------SVSGNRG-------------------------ES-SSESH---- 246

  Fly   375 SSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDG 439
                                  |:|.||
Mouse   247 ----------------------KARVAK------------------------------------- 252

  Fly   440 GSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQK 504
                                                                             
Mouse   253 ----------------------------------------------------------------- 252

  Fly   505 KTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFIT 569
                              :||:||:|||:.:..|::.|||:.:..::          :.|..|||
Mouse   253 ------------------RERKAAKTLGVTVVAFMVSWLPYTIDALV----------DAFMGFIT 289

  Fly   570 ---------WLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
                     |..|.||.:||:||..|...:::|.|.:|
Mouse   290 PAYVYEICCWGTYYNSAMNPLIYAFFFPWFKKAIKLIL 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	70/178 (39%)
		TM helix 1	111..137	CDD:320188	8/15 (53%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	16/29 (55%)
		TM helix 4	224..247	CDD:320188	7/28 (25%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	24/83 (29%)
		TM helix 6	528..550	CDD:410628	8/21 (38%)
		TM helix 7	562..587	CDD:410628	12/33 (36%)
Taar8a	NP_001010830.1	7tm_GPCRs	32..323	CDD:475119	111/487 (23%)
		TM helix 1	34..58	CDD:320439	8/14 (57%)
		TM helix 2	67..89	CDD:320439	12/21 (57%)
		TM helix 3	105..127	CDD:320439	11/21 (52%)
		TM helix 4	150..166	CDD:320439	7/15 (47%)
		TM helix 5	194..217	CDD:320439	9/23 (39%)
		TM helix 6	258..280	CDD:320439	8/21 (38%)
		TM helix 7	291..316	CDD:320439	8/24 (33%)