DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oct-TyrR and octr-1

DIOPT Version :9

Sequence 1:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001024569.1	Gene:	octr-1 / 184469	WormBaseID:	WBGene00006411	Length:	408	Species:	Caenorhabditis elegans

Alignment Length:	497	Identity:	160/497 - (32%)
Similarity:	244/497 - (49%)	Gaps:	129/497 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 EALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIV-QNFFIVSLAVADLTVALLVLPFNVAYSI 171
            ||:||...:..:::|.|.||:||:::|:..:.||:. ||:.||||||||:.|.|||:|..:.|.|
Worm    20 EAVLTISSMLTVMLLIIFGNLLVVVTVYRDRKLRMQRQNWLIVSLAVADMLVGLLVMPLTLTYEI 84

  Fly   172 LGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLL 236
            :|.|..|..||::||..|||..|:|||::|||:||||:::|.|:.|...||..|:.:.|...|::
Worm    85 VGEWTMGNILCEIWLALDVLFVTASILHICAISLDRYFSVTSPLTYPATRTPLRMFIYIGVSWIV 149

  Fly   237 SLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVAT----R 297
            ||||..||:.||.  |:.  :...|.:::..|||:|||||||:||:.|:.|||.:|:..|    |
Worm   150 SLLICLPPIFGWR--PER--AEGECSVSTDLGYVLYSSLGSFYIPVVILIIVYAKIYSITIRHSR 210

  Fly   298 RRLRE-RARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQND 361
            :||:| ..|.:.||.:.::|:                                         .|:
Worm   211 QRLKETERRDHTLNMLTIRSS-----------------------------------------TNE 234

  Fly   362 QESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEP 426
            :.::..|..:           ||||.:.      :|.:....:|.|             :..|
Worm   235 RYNMEYELEE-----------NSDPIED------EKEKVVTNRDMI-------------NKVC-- 267

  Fly   427 HGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSS 491
               .||                       .:||.|.   |:..::|.:.......|    ||.|.
Worm   268 ---WQL-----------------------RKISEEL---PRQGVKVSIALDTNHNS----PPASD 299

  Fly   492 TGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQ 556
            .      ...|::|     :|.|::::...:|||:|...||||:..|::.||||||:|||..|..
Worm   300 L------TRKLEEK-----KFCEKRKRKLKAKERQATLLLGIILSAFILSWLPFFLIYVIGAFGH 353

  Fly   557 TCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            . .|...|| |..||||.|||:||||||:||.:::|...:.|
Worm   354 E-APPLVFK-FFFWLGYCNSGINPVIYTVFNREFKRGLCKQL 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	59/131 (45%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	79/167 (47%)
octr-1	NP_001024569.1	7tmA_alpha2_AR	22..389	CDD:320187	157/489 (32%)
		TM helix 1	24..48	CDD:320187	8/23 (35%)
		TM helix 2	58..80	CDD:320187	14/21 (67%)
		TM helix 3	96..118	CDD:320187	12/21 (57%)
		TM helix 4	141..157	CDD:320187	6/15 (40%)
		TM helix 5	176..199	CDD:320187	15/22 (68%)
		TM helix 6	322..347	CDD:320187	13/24 (54%)
		TM helix 7	357..382	CDD:320187	16/25 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920