Protein Alignment Oct-TyrR and DRD2

DIOPT Version :9

• Sequence 1: NP_001163494.1
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_000786.1
• Gene: DRD2 / 1813
• HGNCID: 3023
• Length: 443
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 158/514 - (30%)
• Similarity: 240/514 - (46%)
• Gaps: 138/514 - (26%)

  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177
            |.:|:::|.:.:.||:||.::|...|.|:...|:.|||||||||.||.||:|:.|...::|.|:|
Human    38 ATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF 102

  Fly   178 G-IHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPI----NYAQKRTVGRVLLLISGVWLLS 237
            . || |.:::|.||:.||:||||||||::|||.|:..|:    .|:.||   ||.::||.||:||
Human   103 SRIH-CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKR---RVTVMISIVWVLS 163

  Fly   238 LLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRR--- 299
            ..||.|.|.|.|:     .....| :.:...:|:|||:.||::|..:..:|||:|::..|||
Human   164 FTISCPLLFGLNN-----ADQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKR 222

  Fly   300 -------------LRERARAN-------KLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWL 344
                         ||...:.|       ||.|:.:||.      .|.||
Human   223 VNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSN------GSFPV---------------- 265

  Fly   345 CCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKH 409
              .|.|.:.|....:.:.|.:||.:  |.:.::..|    .|...|.:.|...|..
Human   266 --NRRRVEAARRAQELEMEMLSSTS--PPERTRYSP----IPPSHHQLTLPDPSHH--------- 313

  Fly   410 GKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCV 474
                 |..|...|..:|.                 ..||:......|:| .|..:.|.|
Human   314 -----GLHSTPDSPAKPE-----------------KNGHAKDHPKIAKI-FEIQTMPNG------ 349

  Fly   475 TQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFV 539
               ..:||||..                            .::|:|..||::|.:.|.|::|||:
Human   350 ---KTRTSLKTM----------------------------SRRKLSQQKEKKATQMLAIVLGVFI 383

  Fly   540 ICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            |||||||:.:::...|....|...:..| |||||:||.:||:|||.||:::|:||.::|
Human   384 ICWLPFFITHILNIHCDCNIPPVLYSAF-TWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	63/135 (47%)
		7tm_1	126..>293	CDD:278431	75/171 (44%)
DRD2	NP_000786.1	7tmA_D2_dopamine_R	35..437	CDD:320435	155/508 (31%)
		TM helix 1	37..61	CDD:320435	8/22 (36%)
		TM helix 2	70..92	CDD:320435	15/21 (71%)
		TM helix 3	108..130	CDD:320435	13/21 (62%)
		TM helix 4	154..170	CDD:320435	8/15 (53%)
		TM helix 5	187..210	CDD:320435	8/22 (36%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..373		47/260 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..332		15/87 (17%)
		TM helix 6	372..394	CDD:320435	12/21 (57%)
		TM helix 7	405..430	CDD:320435	13/25 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910