Protein Alignment Oct-TyrR and DRD1

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_000785.1
• Gene: DRD1 / 1812
• HGNCID: 3020
• Length: 446
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 150/543 - (27%)
• Similarity: 211/543 - (38%)
• Gaps: 228/543 - (41%)

  Fly    82 SAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRI-VQN 145
            ||.:..|.|.|...|:           .:|||..||::|:.|::||.||..:|..::.||. |.|
Human     7 SAMDGTGLVVERDFSV-----------RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN 60

  Fly   146 FFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWA 210
            ||::||||:||.||:||:|:.....|.|.|.|| ..|.:|:..|::|.|:||||||.|::|||||
Human    61 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWA 124

  Fly   211 ITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPL-IGWNDWPDEFTSATP-------------- 260
            |:.|..|.:|.|.....:|||..|.||:|||..|: :.|:       .|.|
Human   125 ISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWH-------KAKPTSPSDGNATSLAET 182

  Fly   261 ---CELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPM 322
               |:.:..|.|.|.||:.||:||:|||.:.|..|:...::::|
Human   183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIR--------------------- 226

  Fly   323 ANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQ 387
                                                                             
Human   227 ----------------------------------------------------------------- 226

  Fly   388 QQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGG 452
                       |.|..:.:..|.|                             :||.   .:|.|
Human   227 -----------RIAALERAAVHAK-----------------------------NCQT---TTGNG 248

  Fly   453 KSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQ 517
            |            |..|.|                |:||.
Human   249 K------------PVECSQ----------------PESSF------------------------- 260

  Fly   518 KISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQT------CCPTNKFKNFITWLGYINS 576
            |:|..:|.:..:||.:||||||.||||||::..|||||.:      |..:|.|..|: |.|:.||
Human   261 KMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFV-WFGWANS 324

  Fly   577 GLNPVIYTIFNLDYRRAFKRLLG 599
            .|||:||. ||.|:|:||..|||
Human   325 SLNPIIYA-FNADFRKAFSTLLG 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	84/202 (42%)
		TM helix 1	111..137	CDD:320188	12/25 (48%)
		TM helix 2	144..170	CDD:320188	14/25 (56%)
		TM helix 3	182..212	CDD:320188	17/29 (59%)
		TM helix 4	224..247	CDD:320188	10/23 (43%)
		TM helix 5	266..294	CDD:320188	14/27 (52%)
		7tm_GPCRs	<519..594	CDD:475119	38/80 (48%)
		TM helix 6	528..550	CDD:410628	14/21 (67%)
		TM helix 7	562..587	CDD:410628	12/24 (50%)
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	139/509 (27%)
		TM helix 1	25..51	CDD:320443	12/25 (48%)
		TM helix 2	59..86	CDD:320443	14/26 (54%)
		TM helix 3	96..126	CDD:320443	17/29 (59%)
		TM helix 4	138..161	CDD:320443	10/22 (45%)
		TM helix 5	191..221	CDD:320443	14/29 (48%)
		TM helix 6	265..295	CDD:320443	15/29 (52%)
		TM helix 7	310..335	CDD:320443	13/26 (50%)