Protein Alignment Oct-TyrR and Htr6

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_067333.1
• Gene: Htr6 / 15565
• MGIID: 1196627
• Length: 440
• Species: Mus musculus
• Alignment Length: 488
• Identity: 125/488 - (25%)
• Similarity: 181/488 - (37%)
• Gaps: 182/488 - (37%)

  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177
            |..|.|:||||...|.|:|..:.|...||...|||:|||..:||.|.|:|:|..:..::.|||..
Mouse    30 AAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVL 94

  Fly   178 GIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLIS- 241
            ...||.||...||:||::||||||.|:||||..|..|:.|..:.|..|.|.||.|.|.|:.|.|
Mouse    95 ARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASF 159

  Fly   242 SPPLIGWNDWPDEFTSAT-PCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERAR 305
            .|.|:||::.....|||. .|.|.:...||:.:|..:||:|...:...|..|.:|.|::
Mouse   160 LPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQ------ 218

  Fly   306 ANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETH 370
                               :..||:..:|:.:        .|:                 :.||.
Mouse   219 -------------------AVQVASLTTGTAT--------AGQ-----------------ALETL 239

  Fly   371 QPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPA 435
            |...:.:.|.. ::|            |||..||.|
Mouse   240 QVPRTPRPGME-SAD------------SRRLTTKHS----------------------------- 262

  Fly   436 GGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVT 500
                                                                             
Mouse   263 ----------------------------------------------------------------- 262

  Fly   501 PLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFK 565
                                 .|..:|:.||||::.:|.:.|||||:..:....|. |.....|
Mouse   263 ---------------------RKALKASLTLGILLSMFFVTWLPFFVASIAQAVCD-CISPGLF- 304

  Fly   566 NFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            :.:|||||.||.:||:||.:|..|::||..|.:
Mouse   305 DVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFV 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	77/182 (42%)
		TM helix 1	111..137	CDD:320188	10/23 (43%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	11/23 (48%)
		TM helix 5	266..294	CDD:320188	8/27 (30%)
		7tm_GPCRs	<519..594	CDD:475119	29/74 (39%)
		TM helix 6	528..550	CDD:410628	10/21 (48%)
		TM helix 7	562..587	CDD:410628	12/24 (50%)
Htr6	NP_067333.1	7tmA_5-HT6	29..333	CDD:320182	123/482 (26%)
		TM helix 1	29..54	CDD:320182	10/23 (43%)
		TM helix 2	61..87	CDD:320182	12/25 (48%)
		TM helix 3	99..129	CDD:320182	18/29 (62%)
		TM helix 4	141..164	CDD:320182	10/22 (45%)
		TM helix 5	185..214	CDD:320182	8/28 (29%)
		TM helix 6	263..293	CDD:320182	12/29 (41%)
		TM helix 7	301..326	CDD:320182	12/25 (48%)