Protein Alignment Oct-TyrR and Htr5a

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_032340.2
• Gene: Htr5a / 15563
• MGIID: 96283
• Length: 357
• Species: Mus musculus
• Alignment Length: 490
• Identity: 125/490 - (25%)
• Similarity: 197/490 - (40%)
• Gaps: 193/490 - (39%)

  Fly   119 IIVLTIIG---------NILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILG- 173
            ::|||::|         |:||:.::...:....|.:..:.|:|::|:.||:||:|.::.:.:.|
Mouse    41 VLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGR 105

  Fly   174 RWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYA--QKRTVGRVLLLISGVWLL 236
            ||:.|..||:||:.|||||||:||.|:.||||||||:||..:.|.  .::.|..|::|::  |.|
Mouse   106 RWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLT--WAL 168

  Fly   237 SLLISSPPLI-GWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRL 300
            |.:||..||: ||.:...|  .:..|:::.:..|.::|::|:|::||.::..||.:|:.|.:.|:
Mouse   169 STVISLAPLLFGWGETYSE--PSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRM 231

  Fly   301 RERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESI 365
            ..|    |.|::             |||
Mouse   232 GSR----KTNSV-------------SPV------------------------------------- 242

  Fly   366 SSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQ 430
                                |:...|            |::.:|
Mouse   243 --------------------PEAVEV------------KNATQH--------------------- 254

  Fly   431 QLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVA 495
                                                                     ||....|.
Mouse   255 ---------------------------------------------------------PQMVFTVR 262

  Fly   496 AVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCP 560
            ..:||           |..|.......||:|||..:||::||||:||.|||:..:|.|.|....|
Mouse   263 HATVT-----------FQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVP 316

  Fly   561 TNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFK 595
            . .:|:...||||.||..||:|||.||..|..|||
Mouse   317 A-IWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFK 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	68/187 (36%)
		TM helix 1	111..137	CDD:320188	7/26 (27%)
		TM helix 2	144..170	CDD:320188	8/25 (32%)
		TM helix 3	182..212	CDD:320188	21/29 (72%)
		TM helix 4	224..247	CDD:320188	9/23 (39%)
		TM helix 5	266..294	CDD:320188	9/27 (33%)
		7tm_GPCRs	<519..594	CDD:475119	35/74 (47%)
		TM helix 6	528..550	CDD:410628	12/21 (57%)
		TM helix 7	562..587	CDD:410628	12/24 (50%)
Htr5a	NP_032340.2	7tm_GPCRs	41..349	CDD:475119	122/487 (25%)
		TM helix 1	43..67	CDD:410628	7/23 (30%)
		TM helix 2	76..98	CDD:410628	8/21 (38%)
		TM helix 3	115..137	CDD:410628	14/21 (67%)
		TM helix 4	160..176	CDD:410628	7/17 (41%)
		TM helix 5	198..221	CDD:410628	7/22 (32%)
		TM helix 6	284..306	CDD:410628	12/21 (57%)
		TM helix 7	317..342	CDD:410628	12/25 (48%)