Protein Alignment Oct-TyrR and Htr1d

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_032335.2
• Gene: Htr1d / 15552
• MGIID: 96276
• Length: 374
• Species: Mus musculus
• Alignment Length: 529
• Identity: 156/529 - (29%)
• Similarity: 230/529 - (43%)
• Gaps: 186/529 - (35%)

  Fly    87 EGAVEELHASILGLQLAVPEWE-ALLTAL------VLSVIIVLTIIGNILVILSVFTYKPLRIVQ 144
            ||..:|.....|.:..|   |: .:|.||      |||||.:.|::.|..|:.::...|.|....
Mouse     9 EGLPQEASNRSLNVTGA---WDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPA 70

  Fly   145 NFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYW 209
            |:.|.|||..||.|::||:|.::||:....|.||..||.:|::.|:.|||:|||:||.|||||||
Mouse    71 NYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYW 135

  Fly   210 AITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATPCE-------LTSQR 267
            ||||.:.|:::||.|....:|:.||::|:.||.|||. |.       .||..|       .|||.
Mouse   136 AITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF-WR-------QATAHEEMSDCLVNTSQI 192

  Fly   268 GYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASN 332
            .|.|||:.|:|:||..::.|:|..|:||.|.|:        ||..:|.....    .::.:...:
Mouse   193 SYTIYSTCGAFYIPSILLIILYGRIYVAARSRI--------LNPPSLYGKRF----TTAQLITGS 245

  Fly   333 SGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKK 397
            :||.       ||                  |::...|
Mouse   246 AGSS-------LC------------------SLNPSLH--------------------------- 258

  Fly   398 SRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTES 462
                                       |.|                                |.:
Mouse   259 ---------------------------ESH--------------------------------THT 264

  Fly   463 GSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRA 527
            ...|....||.:..||.                                 |.|:::||.::||:|
Mouse   265 VGSPLFFNQVKIKLADS---------------------------------ILERKRISAARERKA 296

  Fly   528 ARTLGIIMGVFVICWLPFFLMYVILPFCQTCC---PTNKFKNFITWLGYINSGLNPVIYTIFNLD 589
            .:|||||:|.|:|||||||::.::||.|:..|   |.  ..:|.|||||:||.:||||||:||.|
Mouse   297 TKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPA--LFDFFTWLGYLNSLINPVIYTVFNED 359

  Fly   590 YRRAFKRLL 598
            :|:||::::
Mouse   360 FRQAFQKVV 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	83/196 (42%)
		TM helix 1	111..137	CDD:320188	11/31 (35%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	19/29 (66%)
		TM helix 4	224..247	CDD:320188	10/22 (45%)
		TM helix 5	266..294	CDD:320188	12/27 (44%)
		7tm_GPCRs	<519..594	CDD:475119	42/77 (55%)
		TM helix 6	528..550	CDD:410628	14/21 (67%)
		TM helix 7	562..587	CDD:410628	14/24 (58%)
Htr1d	NP_032335.2	7tm_GPCRs	32..364	CDD:475119	147/497 (30%)
		TM helix 1	38..62	CDD:320455	8/23 (35%)
		TM helix 2	71..93	CDD:320455	11/21 (52%)
		TM helix 3	109..131	CDD:320455	11/21 (52%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	154..170	CDD:320455	6/15 (40%)
		TM helix 5	192..215	CDD:320455	9/22 (41%)
		TM helix 6	297..319	CDD:320455	14/21 (67%)
		TM helix 7	332..357	CDD:320455	15/26 (58%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353		3/3 (100%)