DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oct-TyrR and Htr1a

DIOPT Version :10

Sequence 1:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_032334.2 Gene:Htr1a / 15550 MGIID:96273 Length:421 Species:Mus musculus


Alignment Length:494 Identity:158/494 - (31%)
Similarity:237/494 - (47%) Gaps:120/494 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 LLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGR 174
            ::|:|:|..:|...::||..|:.::...:.|:.|.|:.|.||||.||.|::||||....|.:|.:
Mouse    37 VITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK 101

  Fly   175 WEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLL 239
            |..|...|.|::..||||||||||:||||||||||||||||:|..|||..|...|||..||:..|
Mouse   102 WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFL 166

  Fly   240 ISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERA 304
            ||.||::||.. |::.::...|.::...||.|||:.|:|:|||.:|.::|..||.|.|.|:|:..
Mouse   167 ISIPPMLGWRT-PEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTV 230

  Fly   305 RANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSET 369
            :                     .|....:|:                            |..:.:
Mouse   231 K---------------------KVEKKGAGT----------------------------SFGTSS 246

  Fly   370 HQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSI----KHGKTRGGRKSQSSSTCEPHGEQ 430
            ..|...|..|..|:.|            .||:....::    .:|..|.|....:....|.|   
Mouse   247 APPPKKSLNGQPGSGD------------CRRSAENRAVGTPCANGAVRQGEDDATLEVIEVH--- 296

  Fly   431 QLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVA 495
                             ..|..|....:.:|||:  ...:..|:.:.:|:|:             
Mouse   297 -----------------RVGNSKGHLPLPSESGA--TSYVPACLERKNERTA------------- 329

  Fly   496 AVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCP 560
                              |.|:|::|::||:..:|||||||.|::||||||::.::||||::.|.
Mouse   330 ------------------EAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCH 376

  Fly   561 TNKFKN-FITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            ..:... .|.||||.||.||||||..||.|::.|||:::
Mouse   377 MPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 86/183 (47%)
TM helix 1 111..137 CDD:320188 7/25 (28%)
TM helix 2 144..170 CDD:320188 13/25 (52%)
TM helix 3 182..212 CDD:320188 23/29 (79%)
TM helix 4 224..247 CDD:320188 11/22 (50%)
TM helix 5 266..294 CDD:320188 13/27 (48%)
7tm_GPCRs <519..594 CDD:475119 38/75 (51%)
TM helix 6 528..550 CDD:410628 14/21 (67%)
TM helix 7 562..587 CDD:410628 13/25 (52%)
Htr1aNP_032334.2 7tmA_5-HT1A_vertebrates 37..411 CDD:320453 155/488 (32%)
TM helix 1 38..64 CDD:320453 7/25 (28%)
TM helix 2 71..97 CDD:320453 13/25 (52%)
TM helix 3 109..139 CDD:320453 23/29 (79%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 133..135 1/1 (100%)
TM helix 4 151..173 CDD:320453 11/21 (52%)
TM helix 5 192..221 CDD:320453 14/28 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..268 9/70 (13%)
TM helix 6 338..368 CDD:320453 16/29 (55%)
TM helix 7 379..404 CDD:320453 13/24 (54%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 396..400 3/3 (100%)

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