DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oct-TyrR and ADRA2C

DIOPT Version :9

Sequence 1:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_000674.2	Gene:	ADRA2C / 152	HGNCID:	283	Length:	462	Species:	Homo sapiens

Alignment Length:	591	Identity:	184/591 - (31%)
Similarity:	270/591 - (45%)	Gaps:	155/591 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AAALTAAAAVSTTKSGSGNAARGYTDSDDDAGMGTEAVANISGSLVEGLTTVTAALSTAQADKDS 82
            ||||..|||.....||:|.             .|:..|||.||:                    |
Human     7 AAALAVAAAAGPNASGAGE-------------RGSGGVANASGA--------------------S 38

  Fly    83 AGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFF 147
            .|...|....  .::.||            |.|:..:||.|::||:||:::|.|.:.||..||.|
Human    39 WGPPRGQYSA--GAVAGL------------AAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLF 89

  Fly   148 IVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAIT 212
            :||||.||:.||.||:||::|..::..|.||...|.::|..|||.|||||::||||:|||||::|
Human    90 LVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVT 154

  Fly   213 DPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATP-CELTSQRGYVIYSSLG 276
            ..:.|..|||..||...|..|||:|.:||.|||:.....||  .:|.| |.|..:..|::.|.:|
Human   155 QAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPD--GAAYPQCGLNDETWYILSSCIG 217

  Fly   277 SFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPV------AASNSGS 335
            |||.|..||.:||..|:...:.|.|         |::.|...:.| ..:||.      ||:.:|.
Human   218 SFFAPCLIMGLVYARIYRVAKLRTR---------TLSEKRAPVGP-DGASPTTENGLGAAAGAGE 272

  Fly   336 KSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRR 400
            ...       |....|.     ::.|:.|.::|                           ::.||
Human   273 NGH-------CAPPPAD-----VEPDESSAAAE---------------------------RRRRR 298

  Fly   401 AKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGS- 464
            ...:        ||||:.                ||.:||:....|..:|.|.:::...|.|.|
Human   299 GALR--------RGGRRR----------------AGAEGGAGGADGQGAGPGAAESGALTASRSP 339

  Fly   465 DPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAAR 529
            .|.|.:.                 ::|:......::..::..|.|.     ::|::.::|:|...
Human   340 GPGGRLS-----------------RASSRSVEFFLSRRRRARSSVC-----RRKVAQAREKRFTF 382

  Fly   530 TLGIIMGVFVICWLPFFLMYVILPFCQTCC--PTNKFKNFITWLGYINSGLNPVIYTIFNLDYRR 592
            .|.::|||||:||.|||..|.:...|:..|  |...|| |..|:||.||.|||||||:||.|:||
Human   383 VLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK-FFFWIGYCNSSLNPVIYTVFNQDFRR 446

  Fly   593 AFKRLL 598
            :||.:|
Human   447 SFKHIL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	65/130 (50%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	80/167 (48%)
ADRA2C	NP_000674.2	7tmA_alpha2C_AR	60..448	CDD:320446	158/485 (33%)
		TM helix 2	86..112	CDD:320446	16/25 (64%)
		TM helix 3	124..154	CDD:320446	19/29 (66%)
		TM helix 4	166..189	CDD:320446	12/22 (55%)
		TM helix 5	207..236	CDD:320446	12/28 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..347		30/181 (17%)
		TM helix 6	375..405	CDD:320446	14/29 (48%)
		TM helix 7	416..441	CDD:320446	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020