DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oct-TyrR and ADRA2A

DIOPT Version :10

Sequence 1:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_000672.3 Gene:ADRA2A / 150 HGNCID:281 Length:465 Species:Homo sapiens


Alignment Length:542 Identity:174/542 - (32%)
Similarity:254/542 - (46%) Gaps:113/542 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 AALSTAQADKDSAG----ECEGAVEELHASILGLQLAVPEWEALLTALVLS-VIIVLTIIGNILV 130
            |.:.:.|.|..:|.    |..|.         |.:......:..||.:.|: ::::||:.||:||
Human    14 APMGSLQPDAGNASWNGTEAPGG---------GARATPYSLQVTLTLVCLAGLLMLLTVFGNVLV 69

  Fly   131 ILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTS 195
            |::|||.:.|:..||.|:||||.||:.||.||:||::|..::|.|.||...|:::|..|||.|||
Human    70 IIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTS 134

  Fly   196 SILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLI-----GWNDWPDEF 255
            ||::||||:|||||:||..|.|..|||..|:..:|..||::|.:||.||||     |....|.  
Human   135 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQ-- 197

  Fly   256 TSATP-CELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALK--ST 317
             .|.| ||:..|:.|||.|.:||||.|..||.:||:.|:...:||.|........:.:|..  .|
Human   198 -PAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGT 261

  Fly   318 ELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHG 382
            |..|.......:|...|:::..|.:.|                        ...|.:.:.|||  
Human   262 ERRPNGLGPERSAGPGGAEAEPLPTQL------------------------NGAPGEPAPAGP-- 300

  Fly   383 NSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGG 447
                               :..|::.        ..:|||:  .|.|:       ..|..:|..|
Human   301 -------------------RDTDALD--------LEESSSS--DHAER-------PPGPRRPERG 329

  Fly   448 HSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQF 512
            ..|.||:.|                  :|.....||....| .:||:...:..|.:::.....  
Human   330 PRGKGKARA------------------SQVKPGDSLPRRGP-GATGIGTPAAGPGEERVGAAK-- 373

  Fly   513 IEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPF-CQTCCPTNKFKNFITWLGYINS 576
             ..:.:...::|:|....|.:::||||:||.|||..|.:... |..  |...|| |..|.||.||
Human   374 -ASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSV--PRTLFK-FFFWFGYCNS 434

  Fly   577 GLNPVIYTIFNLDYRRAFKRLL 598
            .||||||||||.|:|||||::|
Human   435 SLNPVIYTIFNHDFRRAFKKIL 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 92/190 (48%)
TM helix 1 111..137 CDD:320188 12/26 (46%)
TM helix 2 144..170 CDD:320188 16/25 (64%)
TM helix 3 182..212 CDD:320188 19/29 (66%)
TM helix 4 224..247 CDD:320188 11/27 (41%)
TM helix 5 266..294 CDD:320188 15/27 (56%)
7tm_GPCRs <519..594 CDD:475119 36/75 (48%)
TM helix 6 528..550 CDD:410628 10/21 (48%)
TM helix 7 562..587 CDD:410628 16/24 (67%)
ADRA2ANP_000672.3 7tmA_alpha2A_AR 49..452 CDD:320445 163/492 (33%)
TM helix 1 50..76 CDD:320445 11/25 (44%)
TM helix 2 83..109 CDD:320445 16/25 (64%)
TM helix 3 121..151 CDD:320445 19/29 (66%)
TM helix 4 163..186 CDD:320445 10/22 (45%)
TM helix 5 208..237 CDD:320445 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..368 33/206 (16%)
PHA03307 244..>389 CDD:223039 34/228 (15%)
TM helix 6 382..412 CDD:320445 13/29 (45%)
TM helix 7 420..445 CDD:320445 16/25 (64%)

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