Protein Alignment Oct-TyrR and ADRA1B

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_011532737.1
• Gene: ADRA1B / 147
• HGNCID: 278
• Length: 556
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 135/528 - (25%)
• Similarity: 210/528 - (39%)
• Gaps: 209/528 - (39%)

  Fly   109 ALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILG 173
            |:...|||...|:..|:|||||||||...:.||...|:|||:||:|||.::..||||:.|..:||
Human    45 AISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG 109

  Fly   174 RWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSL 238
            .|..|...|.:|...||||||:|||:||||::|||..:...:.|....|..:.:|.:..||:||.
Human   110 YWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLST 174

  Fly   239 LISSPPLIGWND-WPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRE 302
            :||..||:||.: .|::   ...|.:|.:..|.::||||||:||||::.::|..:::..:|
Human   175 VISIGPLLGWKEPAPND---DKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKR---- 232

  Fly   303 RARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISS 367
                   .|..|::..::.|:||..:
Human   233 -------TTKNLEAGVMKEMSNSKEL--------------------------------------- 251

  Fly   368 ETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQL 432
                                          :.|..:|:.  |..|....|::
Human   252 ------------------------------TLRIHSKNF--HEDTLSSTKAK------------- 271

  Fly   433 LPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAV 497
                          ||:                                      |:||..|
Human   272 --------------GHN--------------------------------------PRSSIAV--- 281

  Fly   498 SVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFL--------------- 547
                               :....|:|::||:||||::|:|::||||||:
Human   282 -------------------KLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLDPDSPPPTHLR 327

  Fly   548 -------------MYVILP--------FCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYR 591
                         :.::||        ...|..|.:.....:.||||.||.|||:||...:.:::
Human   328 VVPAPWGHSSIMNLPLVLPLDATRSGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFK 392

  Fly   592 RAFKRLLG 599
            |||.|:||
Human   393 RAFVRILG 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	80/184 (43%)
		TM helix 1	111..137	CDD:320188	14/25 (56%)
		TM helix 2	144..170	CDD:320188	14/25 (56%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	12/27 (44%)
		7tm_GPCRs	<519..594	CDD:475119	32/110 (29%)
		TM helix 6	528..550	CDD:410628	13/49 (27%)
		TM helix 7	562..587	CDD:410628	11/24 (46%)
ADRA1B	XP_011532737.1	7tmA_alpha1B_AR	46..395	CDD:320449	129/520 (25%)
		TM helix 1	47..73	CDD:320449	14/25 (56%)
		TM helix 2	80..106	CDD:320449	14/25 (56%)
		TM helix 3	118..148	CDD:320449	18/29 (62%)
		TM helix 4	160..183	CDD:320449	9/22 (41%)
		TM helix 5	200..229	CDD:320449	12/28 (43%)
		TM helix 6	287..353	CDD:320449	18/65 (28%)
		TM helix 7	363..388	CDD:320449	11/24 (46%)