DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oct-TyrR and ADORA2A

DIOPT Version :10

Sequence 1:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_000666.2 Gene:ADORA2A / 135 HGNCID:263 Length:412 Species:Homo sapiens


Alignment Length:510 Identity:110/510 - (21%)
Similarity:163/510 - (31%) Gaps:252/510 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 IIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCK 183
            |.||.|:||:||..:|:....|:.|.|:|:||||.||:.|.:|.:||  |.:|...:....|.| 
Human    16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF--AITISTGFCAACHGC- 77

  Fly   184 LWLTCDVLCCT-SSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIG 247
            |::.|.||..| |||.:|.|||:|||.||..|:.|....|..|...:|:..|:||..|...|::|
Human    78 LFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLG 142

  Fly   248 WND--WPDE----------------FTSATPCELTSQRGYVIYSSLGSFF----IPLAIMTIVYI 290
            ||:  .|.|                |....|      ..|::|.   :||    :||.:|..||:
Human   143 WNNCGQPKEGKNHSQGCGEGQVACLFEDVVP------MNYMVYF---NFFACVLVPLLLMLGVYL 198

  Fly   291 EIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFAT 355
            .||:|.||:              ||..|.:|:                                 
Human   199 RIFLAARRQ--------------LKQMESQPL--------------------------------- 216

  Fly   356 PMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQS 420
                                                                             
Human   217 ----------------------------------------------------------------- 216

  Fly   421 SSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKL 485
                                   ||                                        
Human   217 -----------------------PG---------------------------------------- 218

  Fly   486 TPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYV 550
                                         |:.:.:|.||..||::|.||:|:|.:||||..::..
Human   219 -----------------------------ERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINC 254

  Fly   551 ILPFCQTCCPTNKFKNFITWLGYI-------NSGLNPVIYTIFNLDYRRAFKRLL 598
            ...||..|      .:...||.|:       ||.:||.||.....::|:.|::::
Human   255 FTFFCPDC------SHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII 303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 71/197 (36%)
TM helix 1 111..137 CDD:320188 9/17 (53%)
TM helix 2 144..170 CDD:320188 13/25 (52%)
TM helix 3 182..212 CDD:320188 17/30 (57%)
TM helix 4 224..247 CDD:320188 7/22 (32%)
TM helix 5 266..294 CDD:320188 10/31 (32%)
7tm_GPCRs <519..594 CDD:475119 27/81 (33%)
TM helix 6 528..550 CDD:410628 10/21 (48%)
TM helix 7 562..587 CDD:410628 9/31 (29%)
ADORA2ANP_000666.2 7tmA_Adenosine_R_A2A 7..299 CDD:320196 109/504 (22%)
TM helix 1 8..34 CDD:320196 9/17 (53%)
TM helix 2 41..68 CDD:320196 14/28 (50%)
TM helix 3 77..107 CDD:320196 17/30 (57%)
TM helix 4 121..139 CDD:320196 5/17 (29%)
TM helix 5 174..204 CDD:320196 11/32 (34%)
TM helix 6 226..256 CDD:320196 13/29 (45%)
TM helix 7 267..292 CDD:320196 9/24 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 391..412
Blue background indicates that the domain is not in the aligned region.

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