Protein Alignment Oct-TyrR and Drd2

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_034207.2
• Gene: Drd2 / 13489
• MGIID: 94924
• Length: 444
• Species: Mus musculus
• Alignment Length: 510
• Identity: 158/510 - (30%)
• Similarity: 246/510 - (48%)
• Gaps: 129/510 - (25%)

  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177
            |::|:::|.:.:.||:||.::|...|.|:...|:.|||||||||.||.||:|:.|...::|.|:|
Mouse    38 AMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF 102

  Fly   178 G-IHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPI----NYAQKRTVGRVLLLISGVWLLS 237
            . || |.:::|.||:.||:||||||||::|||.|:..|:    .|:.||   ||.::|:.||:||
Mouse   103 SRIH-CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKR---RVTVMIAIVWVLS 163

  Fly   238 LLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRE 302
            ..||.|.|.|.|:     |....| :.:...:|:|||:.||::|..:..:|||:|::..|:| |:
Mouse   164 FTISCPLLFGLNN-----TDQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKR-RK 221

  Fly   303 RA---------RANKLNTIALKSTELEPMANSSPVAASNSG---SKSRLLASWLCCGRDRAQFAT 355
            |.         |||....:....|..|.|...:.:..||..   ::.|:.|:      .|||
Mouse   222 RVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAA------RRAQ--- 277

  Fly   356 PMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQS 420
               :.:.|.:||.:  |.:.::..|    .|...|.:.|...|..              |..|..
Mouse   278 ---ELEMEMLSSTS--PPERTRYSP----IPPSHHQLTLPDPSHH--------------GLHSNP 319

  Fly   421 SSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEIST-------ESGSDPKGCIQVCVTQAD 478
            .|..:|.                 ..||       |:|..       |..:.|.|         .
Mouse   320 DSPAKPE-----------------KNGH-------AKIVNPRIAKFFEIQTMPNG---------K 351

  Fly   479 EQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWL 543
            .:||||..                            .::|:|..||::|.:.|.|::|||:||||
Mouse   352 TRTSLKTM----------------------------SRRKLSQQKEKKATQMLAIVLGVFIICWL 388

  Fly   544 PFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            |||:.:::...|....|...:..| |||||:||.:||:|||.||:::|:||.::|
Mouse   389 PFFITHILNIHCDCNIPPVLYSAF-TWLGYVNSAVNPIIYTTFNIEFRKAFMKIL 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	79/185 (43%)
		TM helix 1	111..137	CDD:320188	8/23 (35%)
		TM helix 2	144..170	CDD:320188	16/25 (64%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	11/22 (50%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	34/74 (46%)
		TM helix 6	528..550	CDD:410628	12/21 (57%)
		TM helix 7	562..587	CDD:410628	13/24 (54%)
Drd2	NP_034207.2	7tmA_D2_dopamine_R	35..438	CDD:320435	155/504 (31%)
		TM helix 1	36..62	CDD:320435	8/23 (35%)
		TM helix 2	69..92	CDD:320435	15/22 (68%)
		TM helix 3	107..137	CDD:320435	18/29 (62%)
		TM helix 4	152..170	CDD:320435	8/17 (47%)
		TM helix 5	186..211	CDD:320435	9/24 (38%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..374		47/256 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..329		13/83 (16%)
		TM helix 6	367..397	CDD:320435	15/29 (52%)
		TM helix 7	406..431	CDD:320435	13/25 (52%)