Protein Alignment Oct-TyrR and Drd1

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_034206.1
• Gene: Drd1 / 13488
• MGIID: 99578
• Length: 446
• Species: Mus musculus
• Alignment Length: 509
• Identity: 141/509 - (27%)
• Similarity: 200/509 - (39%)
• Gaps: 204/509 - (40%)

  Fly   110 LLTALVLSVIIVLTIIGNILVILSVFTYKPLRI-VQNFFIVSLAVADLTVALLVLPFNVAYSILG 173
            :|||..||::|:.|::||.||..:|..::.||. |.|||::||||:||.||:||:|:.....|.|
Mouse    23 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 87

  Fly   174 RWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSL 238
            .|.|| ..|.:|:..|::|.|:||||||.|::||||||:.|..|.:|.|.....:|||..|.||:
Mouse    88 FWPFG-SFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSV 151

  Fly   239 LISSPPL-IGWN----DWP--DEFTSATP-----CELTSQRGYVIYSSLGSFFIPLAIMTIVYIE 291
            |||..|: :.|:    .||  ..|||...     |:....|.|.|.|||.||:||:|||.:.|..
Mouse   152 LISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTS 216

  Fly   292 IFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATP 356
            |:...::::|   |.:.|...|:
Mouse   217 IYRIAQKQIR---RISALERAAV------------------------------------------ 236

  Fly   357 MIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSS 421
                                                                |.|
Mouse   237 ----------------------------------------------------HAK---------- 239

  Fly   422 STCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLT 486
                               :||               :|....:|..|.|
Mouse   240 -------------------NCQ---------------TTTGNGNPVECSQ--------------- 255

  Fly   487 PPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVI 551
                                      .|...|:|..:|.:..:||.:||||||.||||||:...:
Mouse   256 --------------------------SESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCM 294

  Fly   552 LPFCQT------CCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLG 599
            :|||.:      |..:..|..|: |.|:.||.|||:||. ||.|:::||..|||
Mouse   295 VPFCGSEETQPFCIDSITFDVFV-WFGWANSSLNPIIYA-FNADFQKAFSTLLG 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	88/196 (45%)
		TM helix 1	111..137	CDD:320188	12/25 (48%)
		TM helix 2	144..170	CDD:320188	14/25 (56%)
		TM helix 3	182..212	CDD:320188	17/29 (59%)
		TM helix 4	224..247	CDD:320188	10/23 (43%)
		TM helix 5	266..294	CDD:320188	15/27 (56%)
		7tm_GPCRs	<519..594	CDD:475119	34/80 (43%)
		TM helix 6	528..550	CDD:410628	14/21 (67%)
		TM helix 7	562..587	CDD:410628	11/24 (46%)
Drd1	NP_034206.1	7tm_GPCRs	22..341	CDD:475119	136/502 (27%)
		TM helix 1	25..49	CDD:410628	11/23 (48%)
		TM helix 2	59..81	CDD:410628	14/21 (67%)
		TM helix 3	96..118	CDD:410628	11/21 (52%)
		TM helix 4	141..157	CDD:410628	9/15 (60%)
		TM helix 5	192..215	CDD:410628	13/22 (59%)
		TM helix 6	271..293	CDD:410628	14/21 (67%)
		TM helix 7	310..335	CDD:410628	12/26 (46%)