Protein Alignment Oct-TyrR and TAAR9

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 107/504 - (21%)
• Similarity: 155/504 - (30%)
• Gaps: 235/504 - (46%)

  Fly   115 VLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGI 179
            ||....||...||:||::::..:|.|....||.|.|||.||..|.:.|:||:...|:...|.||.
Human    38 VLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGD 102

  Fly   180 HLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGV-----WLLSLL 239
            ..||.....|...|.:|:.:||.|::|||.|:|||:.|..|.||.     :||:     |..|:.
Human   103 SYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVS-----VSGICIVLSWFFSVT 162

  Fly   240 IS-SPPLIGWNDWPDE-----FTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRR 298
            .| |....|.|:...|     .|....|:....:.:|:...| .||||...|..:|.:||:..:.
Human   163 YSFSIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFL-LFFIPNVAMVFIYSKIFLVAKH 226

  Fly   299 RLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQE 363
            :.|:
Human   227 QARK------------------------------------------------------------- 230

  Fly   364 SISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHG 428
             |.|...|.|.||::                 .|.|.||
Human   231 -IESTASQAQSSSES-----------------YKERVAK-------------------------- 251

  Fly   429 EQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTG 493
                                                                             
Human   252 ----------------------------------------------------------------- 251

  Fly   494 VAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTC 558
                                         :||:||:||||.|..|::.|||:.:..||
Human   252 -----------------------------RERKAAKTLGIAMAAFLVSWLPYLVDAVI------- 280

  Fly   559 CPTNKFKNFIT---------WLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
               :.:.||||         |..|.||.:||:||..|...:.:|.|.::
Human   281 ---DAYMNFITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIV 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	65/189 (34%)
		TM helix 1	111..137	CDD:320188	8/21 (38%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	12/29 (41%)
		TM helix 4	224..247	CDD:320188	6/28 (21%)
		TM helix 5	266..294	CDD:320188	9/27 (33%)
		7tm_GPCRs	<519..594	CDD:475119	28/83 (34%)
		TM helix 6	528..550	CDD:410628	10/21 (48%)
		TM helix 7	562..587	CDD:410628	12/33 (36%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	105/498 (21%)
		TM helix 1	34..60	CDD:320439	8/21 (38%)
		TM helix 2	67..93	CDD:320439	12/25 (48%)
		TM helix 3	105..135	CDD:320439	12/29 (41%)
		TM helix 4	147..170	CDD:320439	6/27 (22%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		2/12 (17%)
		TM helix 5	194..223	CDD:320439	10/29 (34%)
		TM helix 6	251..281	CDD:320439	16/159 (10%)
		TM helix 7	290..315	CDD:320439	8/24 (33%)