Protein Alignment Oct-TyrR and Dop1R1

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_061506303.1
• Gene: Dop1R1 / 1275919
• VectorBaseID: AGAMI1_010805
• Length: 445
• Species: Anopheles gambiae
• Alignment Length: 612
• Identity: 156/612 - (25%)
• Similarity: 228/612 - (37%)
• Gaps: 250/612 - (40%)

  Fly     9 FVNVTTTVAAAALTAAAAVSTTKSGSGNAARGYTDSDDDAGMGTEAVANISGSLVEGLTTVTAAL 73
            :::.|:||          ||.|..|:..:......|.|.:|.||.|   .||:.:.|
Mosquito    13 YLSSTSTV----------VSATTIGNLTSVNQTDGSGDGSGSGTGA---SSGTGIPG-------- 56

  Fly    74 STAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYK 138
               ...:|:..:....:..|..|.||              :.||::|.|::.|||||.::::|.:
Mosquito    57 ---GPGEDTDDDDVDVLSPLSMSFLG--------------VFLSIVIFLSVAGNILVCIAIYTER 104

  Fly   139 PLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAI 203
            .||.:.|.|:.|||:|||.||.||:.|.....:||.|.||...|..|:..||:|.|:||||||||
Mosquito   105 SLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAI 169

  Fly   204 ALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPP--LIGWNDWPDEFTSA-------- 258
            :||||..|.||:.|.:..|....:..|:.:|||:.|:|..|  |....|..|:..::
Mosquito   170 SLDRYIHIKDPLRYGRWVTRRVAIGTIAVIWLLAALVSFVPISLDLHRDKRDKTDTSLKINGIKY 234

  Fly   259 TPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMA 323
            ..|.|.....|.:.||..||::|..:|..:|..::
Mosquito   235 ETCALDLTPTYAVVSSCISFYVPCIVMIGIYCRLY------------------------------ 269

  Fly   324 NSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQ 388
                                 |..                                        |
Mosquito   270 ---------------------CYA----------------------------------------Q 273

  Fly   389 QHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGK 453
            :||     ||.||.|:                                       ||
Mosquito   274 KHV-----KSIRAVTR---------------------------------------PG-------- 286

  Fly   454 SDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQK 518
               |||                   |:....:..|:||                        |.|
Mosquito   287 ---EIS-------------------EKRYRSIRRPKSS------------------------KNK 305

  Fly   519 ISLSK------------ERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWL 571
            :.|.:            :.:||.|:|:|||||:|||:|||.:.:|..||:||.....|| .::||
Mosquito   306 LKLRQLAHTASSPYHVSDHKAAITVGVIMGVFLICWVPFFCVNIIAAFCKTCIGQQTFK-VLSWL 369

  Fly   572 GYINSGLNPVIYTIFNLDYRRAFKRLL 598
            ||.||..||:||:|||.::|.||||:|
Mosquito   370 GYSNSAFNPIIYSIFNTEFREAFKRIL 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	73/193 (38%)
		TM helix 1	111..137	CDD:320188	9/25 (36%)
		TM helix 2	144..170	CDD:320188	13/25 (52%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	8/24 (33%)
		TM helix 5	266..294	CDD:320188	8/27 (30%)
		7tm_GPCRs	<519..594	CDD:475119	37/86 (43%)
		TM helix 6	528..550	CDD:410628	14/21 (67%)
		TM helix 7	562..587	CDD:410628	13/24 (54%)
Dop1R1	XP_061506303.1	None