Protein Alignment Oct-TyrR and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_061500179.1
• Gene: 5-HT2A / 1269329
• VectorBaseID: AGAMI1_010455
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 660
• Identity: 185/660 - (28%)
• Similarity: 279/660 - (42%)
• Gaps: 159/660 - (24%)

  Fly     3 SADQILFVNVTTTVAAAALTAAAA---VSTTKSGSGNAARGYTDSDDDAG--MGTEAVANISGSL 62
            :|.|.|......|.|..:.||.|.   |.:.:...||.:   |:|...||  ..::|...:|.||
Mosquito   194 NASQALLDAERPTPAQPSQTARAVPGPVQSVRLVCGNVS---TESPLAAGSLFESDAFELVSVSL 255

  Fly    63 VEGLTT-VTAALSTAQADKDSAGECEGAVEELHASILG---LQL---------AVP---EWEALL 111
            :|.:.. :...|..|..   |.....||.....|::.|   .||         ..|   ||..|.
Mosquito   256 LEPIQCWMNVELRNALV---SPTWLNGAEHHAVAALAGWNQTQLLGELPAGGDTAPGRYEWSFLF 317

  Fly   112 TALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWE 176
            ..|    .|....:|||||.|:|...:.|:.|.|:|::|||:|||.|:|.|:|.......||.|.
Mosquito   318 VIL----FIFAGGLGNILVCLAVALDRKLQNVTNYFLLSLAIADLLVSLFVMPLGAIPGFLGYWP 378

  Fly   177 FGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPI---NYAQKRTVGRVLLLISGVWLLSL 238
            ||:..|.:::|||||.|::|||::|.|:|.||..|.:|:   :::.||..|   :.|:.||||::
Mosquito   379 FGVTWCNIYVTCDVLACSASILHMCFISLGRYLGIRNPLGSRHHSTKRLTG---IKIALVWLLAM 440

  Fly   239 LISSP-PLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRE 302
            |:||. .::|..:..:.......| :.:.|.:.::.||.:|:||:.:|.:.|    ..|.:.||:
Mosquito   441 LVSSSITVLGMINQNNIMPGPNEC-VINNRAFFVFGSLVAFYIPMVMMVVTY----ALTVQLLRK 500

  Fly   303 RARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISS 367
            :||          ..|..|           .|...|.|...|...:..        .|.|...||
Mosquito   501 KAR----------FLEQHP-----------EGELFRRLGGRLASSKHS--------NNSQSDGSS 536

  Fly   368 ETHQPQDSSKAGPHGNSDPQQ-QHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQ 431
            .:::..:..|...:.|..|.. ||              ||           |..||
Mosquito   537 TSNKAVEMRKFTVNNNKQPAYGQH--------------DS-----------SPPSS--------- 567

  Fly   432 LLPAGGDGGSCQPGGGH---SGGGKSDAEISTESG--SDP--------------KGCIQVCVTQA 477
             ||:...|.|..|...|   :|.||.|:.:|:..|  |.|              |....||
Mosquito   568 -LPSVAAGHSALPWRWHGTTAGTGKMDSRMSSIKGSMSHPHLGYSNGGNRTMAGKRSRTVC---- 627

  Fly   478 DEQTSLKLTPPQSSTGVAAVSVTPLQK-----------KTSGVN---QFIEEKQKISLS-----K 523
            |:.|.   ||.      :....|..||           .|..:|   :|:..|::.:||     .
Mosquito   628 DQGTQ---TPD------SIERETRRQKFCSFRIHLNSVPTPAINFNLKFLGSKKRTNLSANAVAT 683

  Fly   524 ERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNL 588
            |::|.:.||::...||.||.|||::.:|...........:..:...||||::|.:||:||||||.
Mosquito   684 EQKATKVLGLVFFTFVFCWAPFFILNIIFAAWPEAKVPERIVSICLWLGYVSSTINPIIYTIFNK 748

  Fly   589 DYRRAFKRLL 598
            .:|.||.|||
Mosquito   749 TFRAAFIRLL 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	67/187 (36%)
		TM helix 1	111..137	CDD:320188	9/25 (36%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	15/29 (52%)
		TM helix 4	224..247	CDD:320188	9/23 (39%)
		TM helix 5	266..294	CDD:320188	8/27 (30%)
		7tm_GPCRs	<519..594	CDD:475119	28/79 (35%)
		TM helix 6	528..550	CDD:410628	9/21 (43%)
		TM helix 7	562..587	CDD:410628	11/24 (46%)
5-HT2A	XP_061500179.1	None