DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oct-TyrR and Adra2c

DIOPT Version :10

Sequence 1:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_031444.2 Gene:Adra2c / 11553 MGIID:87936 Length:458 Species:Mus musculus


Alignment Length:604 Identity:187/604 - (30%)
Similarity:277/604 - (45%) Gaps:177/604 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VAAAALTAAAAVSTTKSGSGNAARGYTDSDDDAG-MGTEAVANISGSLVEGLTTVTAALSTAQAD 79
            :|:.||.||.|.:..:..:|:          ||| .|:...||.||:                 |
Mouse     1 MASPALAAALAAAAAEGPNGS----------DAGEWGSGGGANASGT-----------------D 38

  Fly    80 ------KDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYK 138
                  :.|||           ::.||            |.|:..:||.|::||:||:::|.|.:
Mouse    39 WVPPPGQYSAG-----------AVAGL------------AAVVGFLIVFTVVGNVLVVIAVLTSR 80

  Fly   139 PLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAI 203
            .||..||.|:||||.||:.||.||:||::|..::..|.||...|.::|..|||.|||||::||||
Mouse    81 ALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAI 145

  Fly   204 ALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATP-CELTSQR 267
            :|||||::|..:.|..|||..||...|..|||:|.:||.|||:.:...||  .:|.| |.|..:.
Mouse   146 SLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPD--GAAYPQCGLNDET 208

  Fly   268 GYVIYSSLGSFFIPLAIMTIVYIEIF-VATRRRLRERARANKLNTI----ALKSTELEPMANSSP 327
            .|::.|.:||||.|..||.:||..|: ||   :||.|..:.|....    |..:||     |...
Mouse   209 WYILSSCIGSFFAPCLIMGLVYARIYRVA---KLRTRTLSEKRGPAGPDGASPTTE-----NGLG 265

  Fly   328 VAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVV 392
            .||..:|.          |...|.:.                 :|.:||.|              
Mouse   266 KAAGENGH----------CAPPRTEV-----------------EPDESSAA-------------- 289

  Fly   393 VLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQ-PGGGHSGGGKSDA 456
                  .|.:.:.:::    ||||:.:.              |.||.||.. ||.|         
Mouse   290 ------ERRRRRGALR----RGGRRREG--------------AEGDTGSADGPGPG--------- 321

  Fly   457 EISTESGSDPKGCIQVCVTQADEQTSLKLTPP-----QSSTGVAAVSVTPLQKKTSGVNQFIEEK 516
             ::.|.|:               :|:.:...|     ::|:......::..::..|.|.     :
Mouse   322 -LAAEQGA---------------RTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVC-----R 365

  Fly   517 QKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCC--PTNKFKNFITWLGYINSGLN 579
            :|::.::|:|....|.::|||||:||.|||..|.:...|:..|  |...|| |..|:||.||.||
Mouse   366 RKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFK-FFFWIGYCNSSLN 429

  Fly   580 PVIYTIFNLDYRRAFKRLL 598
            |||||:||.|:||:||.:|
Mouse   430 PVIYTVFNQDFRRSFKHIL 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 86/185 (46%)
TM helix 1 111..137 CDD:320188 10/25 (40%)
TM helix 2 144..170 CDD:320188 16/25 (64%)
TM helix 3 182..212 CDD:320188 19/29 (66%)
TM helix 4 224..247 CDD:320188 12/22 (55%)
TM helix 5 266..294 CDD:320188 12/28 (43%)
7tm_GPCRs <519..594 CDD:475119 37/76 (49%)
TM helix 6 528..550 CDD:410628 11/21 (52%)
TM helix 7 562..587 CDD:410628 15/24 (63%)
Adra2cNP_031444.2 7tmA_alpha2C_AR 60..444 CDD:320446 161/489 (33%)
TM helix 2 86..112 CDD:320446 16/25 (64%)
TM helix 3 124..154 CDD:320446 19/29 (66%)
TM helix 4 166..189 CDD:320446 12/22 (55%)
TM helix 5 207..236 CDD:320446 12/28 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..343 31/192 (16%)
TM helix 6 371..401 CDD:320446 14/29 (48%)
TM helix 7 412..437 CDD:320446 15/25 (60%)

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