DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oct-TyrR and Adra2b

DIOPT Version :9

Sequence 1:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_033763.3	Gene:	Adra2b / 11552	MGIID:	87935	Length:	448	Species:	Mus musculus

Alignment Length:	496	Identity:	175/496 - (35%)
Similarity:	243/496 - (48%)	Gaps:	77/496 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 TALVLSVI---IVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILG 173
            ||.:.|.|   |:.||.||.||||:|.|.:.||..||.|:||||.||:.||.|::||::|..:||
Mouse    12 TAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLG 76

  Fly   174 RWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSL 238
            .|.|....|:::|..|||.|||||::||||:||||||::..:.|..|||..|:..:|..|||::.
Mouse    77 YWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAA 141

  Fly   239 LISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRER 303
            :||.||||...|...|......|||..:..|::.||:||||.|..||.:||:.|:|..:|. ..|
Mouse   142 VISLPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRS-HCR 205

  Fly   304 ARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSE 368
            ....|..:...:|.:..|.|...|.:|     |...|.|.|....:......|    .:|....|
Mouse   206 GLGAKRGSGEGESKKPHPAAGGVPASA-----KVPTLVSPLSSVGEANGHPKP----PREKEEGE 261

  Fly   369 THQPQDSSKAGPHGNSDP---QQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSS-STCEPHGE 429
            |.:..::....|:.::.|   |.|      ||.....|.:       :|..:.:.. ..|||
Mouse   262 TPEDPEARALPPNWSALPRSVQDQ------KKGTSGATAE-------KGAEEDEEEVEECEP--- 310

  Fly   430 QQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGV 494
             |.|||                       |..|..:|                 .|..||:|..:
Mouse   311 -QTLPA-----------------------SPASVFNP-----------------PLQQPQTSRVL 334

  Fly   495 AAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCC 559
            |.:....|..|..||......:::..||:|:|....|.:::||||:||.|||..|.:...|...|
Mouse   335 ATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHC 399

  Fly   560 --PTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
              |...|: |..|:||.||.||||||||||.|:||||:|:|
Mouse   400 KVPHGLFQ-FFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	66/133 (50%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	81/166 (49%)
Adra2b	NP_033763.3	7tmA_alpha2B_AR	7..435	CDD:320444	171/490 (35%)
		TM helix 1	14..40	CDD:320444	12/25 (48%)
		TM helix 2	47..73	CDD:320444	15/25 (60%)
		TM helix 3	85..115	CDD:320444	20/29 (69%)
		TM helix 4	127..150	CDD:320444	10/22 (45%)
		TM helix 5	169..198	CDD:320444	13/28 (46%)
		PRK12323	<209..354	CDD:237057	41/210 (20%)
		TM helix 6	362..392	CDD:320444	14/29 (48%)
		TM helix 7	403..428	CDD:320444	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010