Protein Alignment Oct-TyrR and Adra1a

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_038489.2
• Gene: Adra1a / 11549
• MGIID: 104773
• Length: 466
• Species: Mus musculus
• Alignment Length: 497
• Identity: 138/497 - (27%)
• Similarity: 209/497 - (42%)
• Gaps: 186/497 - (37%)

  Fly   108 EALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSIL 172
            :|:|..::|..:|:..::|||||||||..::.|..|.:::||:||||||.:...||||:..:.||
Mouse    25 KAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEIL 89

  Fly   173 GRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINY----AQKRTVGRVLLLISGV 233
            |.|.||...|.:|...||||||:||:.||.|::|||..::.|:.|    .|:|.| |.||.   |
Mouse    90 GYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGV-RALLC---V 150

  Fly   234 WLLSLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRR 298
            |.|||:||..||.||.....|  ..|.|::..:.|||::|:||||::||.|:.::|..::|..:|
Mouse   151 WALSLVISIGPLFGWRQQAPE--DETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKR 213

  Fly   299 RLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQE 363
            ..|                                |.||.|...                ::|.|
Mouse   214 ESR--------------------------------GLKSGLKTD----------------KSDSE 230

  Fly   364 SISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHG 428
            .::...|                                             ||:
Mouse   231 QVTLRIH---------------------------------------------RKN---------- 240

  Fly   429 EQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQT--SLKLTPPQSS 491
                :||.|.|                                  |:.|..:|  |::|
Mouse   241 ----VPAEGSG----------------------------------VSSAKNKTHFSVRL------ 261

  Fly   492 TGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQ 556
                                       :..|:|::||:||||::|.||:|||||||:..|..|..
Mouse   262 ---------------------------LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFP 299

  Fly   557 TCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            ...|.......:.||||:||.:||:||...:.::::||:.:|
Mouse   300 NFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	82/187 (44%)
		TM helix 1	111..137	CDD:320188	12/25 (48%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	16/29 (55%)
		TM helix 4	224..247	CDD:320188	12/22 (55%)
		TM helix 5	266..294	CDD:320188	12/27 (44%)
		7tm_GPCRs	<519..594	CDD:475119	31/74 (42%)
		TM helix 6	528..550	CDD:410628	15/21 (71%)
		TM helix 7	562..587	CDD:410628	10/24 (42%)
Adra1a	NP_038489.2	7tmA_alpha1A_AR	27..337	CDD:320448	134/489 (27%)
		TM helix 1	28..54	CDD:320448	12/25 (48%)
		TM helix 2	61..87	CDD:320448	12/25 (48%)
		TM helix 3	99..129	CDD:320448	16/29 (55%)
		TM helix 4	141..164	CDD:320448	14/26 (54%)
		TM helix 5	181..210	CDD:320448	12/28 (43%)
		TM helix 6	265..295	CDD:320448	18/29 (62%)
		TM helix 7	305..330	CDD:320448	10/24 (42%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		3/8 (38%)