Protein Alignment Oct-TyrR and Adora2b

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_031439.2
• Gene: Adora2b / 11541
• MGIID: 99403
• Length: 332
• Species: Mus musculus
• Alignment Length: 512
• Identity: 106/512 - (20%)
• Similarity: 163/512 - (31%)
• Gaps: 234/512 - (45%)

  Fly   108 EALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSIL 172
            :||..||.| ||..|.:.||:||..:|.....|:...|:|:||||.||:.|.|..:||.:..|:.
Mouse     7 DALYVALEL-VIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLG 70

  Fly   173 GRWEFGIHLCKLWLTCDVLCCT-SSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLL 236
            ...:|  |.| |:|.|.||..| |||.:|.|:|:|||.||..|:.|....|..|...:|:.:|:|
Mouse    71 FCTDF--HGC-LFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVL 132

  Fly   237 SLLISSPPLIGWN----------DWPDEFTSATPCELTS------QRGYVIY-SSLGSFFIPLAI 284
            :..|...|.:|||          :..|...:.:.|.:|.      ...|::| :..|....||.|
Mouse   133 AFGIGLTPFLGWNSKDSATSNCTELGDGIANKSCCPVTCLFENVVPMSYMVYFNFFGCVLPPLLI 197

  Fly   285 MTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRD 349
            |.::||:||
Mouse   198 MLVIYIKIF-------------------------------------------------------- 206

  Fly   350 RAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRG 414
                                                      :|..|:.:|.:..|   |.:|
Mouse   207 ------------------------------------------MVACKQLQRMELMD---HSRT-- 224

  Fly   415 GRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADE 479
                                                                             
Mouse   225 ----------------------------------------------------------------- 224

  Fly   480 QTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLP 544
                                                    :|.:|..||::|.:|:|:|.:||||
Mouse   225 ----------------------------------------TLQREIHAAKSLAMIVGIFALCWLP 249

  Fly   545 FFLMYVILPFCQTCCPTNKFK---NFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            ...:..|..| ......:|.|   |....|.:.||.:||::|...|.|:|.:|.:::
Mouse   250 VHAINCITLF-HPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHKII 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	71/201 (35%)
		TM helix 1	111..137	CDD:320188	11/25 (44%)
		TM helix 2	144..170	CDD:320188	12/25 (48%)
		TM helix 3	182..212	CDD:320188	17/30 (57%)
		TM helix 4	224..247	CDD:320188	6/22 (27%)
		TM helix 5	266..294	CDD:320188	10/28 (36%)
		7tm_GPCRs	<519..594	CDD:475119	26/77 (34%)
		TM helix 6	528..550	CDD:410628	9/21 (43%)
		TM helix 7	562..587	CDD:410628	9/27 (33%)
Adora2b	NP_031439.2	7tmA_Adenosine_R_A2B	8..301	CDD:320197	105/505 (21%)
		TM helix 1	9..35	CDD:320197	12/26 (46%)
		TM helix 2	42..69	CDD:320197	12/26 (46%)
		TM helix 3	78..108	CDD:320197	17/30 (57%)
		TM helix 4	122..140	CDD:320197	4/17 (24%)
		TM helix 5	179..209	CDD:320197	11/127 (9%)
		TM helix 6	227..257	CDD:320197	11/29 (38%)
		TM helix 7	269..294	CDD:320197	8/24 (33%)