Protein Alignment Oct-TyrR and htr2c

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_017951833.1
• Gene: htr2c / 100496012
• XenbaseID: XB-GENE-967634
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 567
• Identity: 143/567 - (25%)
• Similarity: 216/567 - (38%)
• Gaps: 211/567 - (37%)

  Fly    59 SGSLVEGLTTVTAALS------------------TAQADKDSAGECEGAVEE--LHASILGLQLA 103
            :|.|| .||||:...|                  |......::.....:.||  .|.|     ||
 Frog     7 TGKLV-SLTTVSITRSVDISFHNGLMAWHVNNNVTLNQSMPTSAPANASEEEKLSHES-----LA 65

  Fly   104 VPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVA 168
            ...|.||||.    :||:|||.||||||::|...|.|:...|||::||||||:.|.:||:|.::.
 Frog    66 DKNWSALLTL----IIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLV 126

  Fly   169 YSILG-RWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISG 232
            ..:.. .|.....||.:|::.|||..|:||::||||:||||.||.:||.:::..:..:.::.|:.
 Frog   127 TILYDYAWPLPRKLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAA 191

  Fly   233 VWLLSLLISSP-PLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVY---IEIF 293
            ||.:|:.||.| |:||..|....|.::: |.|..: .:|:..|..:|||||.||...|   |::.
 Frog   192 VWTISIGISMPVPVIGLQDDSRVFVNSS-CVLNDE-NFVLLGSFVAFFIPLIIMVFTYCLTIQVL 254

  Fly   294 VATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMI 358
                                                                             
 Frog   255 ----------------------------------------------------------------- 254

  Fly   359 QNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVL---VKKSRRAKTKDSIKHGKTRGGRKSQS 420
                                        |:|..|.:   |.|.||:......|...|......|:
 Frog   255 ----------------------------QKQATVFMYEEVPKQRRSSVNCLKKENNTENISMIQN 291

  Fly   421 SSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKL 485
                                       |......::.|:.|.....||.:|
 Frog   292 ---------------------------HEAASHLNSPINKEGALFRKGTMQ-------------- 315

  Fly   486 TPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYV 550
                                              |::.||||::.|||:..:|:|.|.|||:..:
 Frog   316 ----------------------------------SINNERRASKVLGIVFFLFLIMWCPFFITNI 346

  Fly   551 ILPFCQTCCPTN---KFKNFITWLGYINSGLNPVIYTIFNLDYRRAF 594
            :...|:..|...   :..|...|:||::||:||::||:||..|||||
 Frog   347 MSVLCKEACDNELMVELLNVFVWVGYVSSGINPLVYTLFNRTYRRAF 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	77/188 (41%)
		TM helix 1	111..137	CDD:320188	14/25 (56%)
		TM helix 2	144..170	CDD:320188	13/25 (52%)
		TM helix 3	182..212	CDD:320188	17/29 (59%)
		TM helix 4	224..247	CDD:320188	8/23 (35%)
		TM helix 5	266..294	CDD:320188	11/30 (37%)
		7tm_GPCRs	<519..594	CDD:475119	31/77 (40%)
		TM helix 6	528..550	CDD:410628	9/21 (43%)
		TM helix 7	562..587	CDD:410628	10/27 (37%)
htr2c	XP_017951833.1	7tmA_5-HT2C	68..399	CDD:341346	128/500 (26%)
		TM helix 1	69..95	CDD:341346	17/29 (59%)
		TM helix 2	102..128	CDD:341346	13/25 (52%)
		TM helix 3	141..171	CDD:341346	17/29 (59%)
		TM helix 4	183..206	CDD:341346	8/22 (36%)
		TM helix 5	224..253	CDD:341346	11/29 (38%)
		TM helix 6	318..348	CDD:341346	13/29 (45%)
		TM helix 7	361..386	CDD:341346	10/24 (42%)