Protein Alignment Oct-TyrR and drd1c

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: XP_004915948.1
• Gene: drd1c / 100124855
• XenbaseID: XB-GENE-5919679
• Length: 465
• Species: Xenopus tropicalis
• Alignment Length: 557
• Identity: 144/557 - (25%)
• Similarity: 206/557 - (36%)
• Gaps: 230/557 - (41%)

  Fly    63 VEGLTTVTAALSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGN 127
            :|.|:.....::...||.|           :.:|.|.|:        .||.|:||::|:.|::||
 Frog     1 MENLSIYNVTVNVLHADLD-----------VGSSDLSLR--------ALTGLLLSLLILSTLLGN 46

  Fly   128 ILVILSVFTYKPLRI-VQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVL 191
            .||.|:|..::.||. |.|||::||||:||.|||||:|:.....:.|.|.|| ..|..|:..|::
 Frog    47 TLVCLAVIKFRHLRSKVTNFFVISLAVSDLFVALLVMPWKAVTEVAGYWLFG-DFCDTWVAFDIM 110

  Fly   192 CCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPL-IGW--NDWPD 253
            |.|:||||||.|:|||||||..|..|.:|.|.....::|...|.||:|||..|: :.|  :...|
 Frog   111 CSTASILNLCIISLDRYWAIASPFRYERKMTQRVAFIMIGVAWTLSILISFIPVQLSWHKSQEVD 175

  Fly   254 EFTSA----TPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIAL 314
            |..:|    ..|:.:..|.|.|.|||.||:||:.||...|..|:...:.::|
 Frog   176 EELNAINHTENCDSSLNRTYAISSSLISFYIPVVIMIGTYTRIYRIAQTQIR------------- 227

  Fly   315 KSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAG 379
                                                                             
 Frog   228 ----------------------------------------------------------------- 227

  Fly   380 PHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQP 444
                               |.:..:.:::|.::
 Frog   228 -------------------RISSLERAVEHAQS-------------------------------- 241

  Fly   445 GGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGV 509
              ||                                       |..|.
 Frog   242 --GH---------------------------------------PDCSN----------------- 248

  Fly   510 NQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFC----------QTCCPTNKF 564
                |...|.|..||.:..:||.|||||||.||||||::..::|||          :..|.:...
 Frog   249 ----ENSLKTSFRKETKVLKTLSIIMGVFVFCWLPFFVLNCMIPFCHMSLPGQNEPEPPCVSETT 309

  Fly   565 KNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLLGLN 601
            .|...|.|:.||.||||||. ||.|:|:||..:||.|
 Frog   310 FNIFVWFGWANSSLNPVIYA-FNADFRKAFTTILGCN 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	85/191 (45%)
		TM helix 1	111..137	CDD:320188	13/25 (52%)
		TM helix 2	144..170	CDD:320188	15/25 (60%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	8/23 (35%)
		TM helix 5	266..294	CDD:320188	14/27 (52%)
		7tm_GPCRs	<519..594	CDD:475119	37/84 (44%)
		TM helix 6	528..550	CDD:410628	15/21 (71%)
		TM helix 7	562..587	CDD:410628	11/24 (46%)
drd1c	XP_004915948.1	7tmA_D1-like_dopamine_R	46..338	CDD:320185	123/484 (25%)
		TM helix 2	64..91	CDD:320185	15/26 (58%)
		TM helix 3	101..131	CDD:320185	18/29 (62%)
		TM helix 4	143..163	CDD:320185	7/19 (37%)
		TM helix 5	192..222	CDD:320185	14/29 (48%)
		TM helix 6	257..287	CDD:320185	17/29 (59%)
		TM helix 7	307..332	CDD:320185	12/25 (48%)