DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MGAT1 and Mgat1

DIOPT Version :9

Sequence 1:	NP_001108089.1	Gene:	MGAT1 / 4245	HGNCID:	7044	Length:	445	Species:	Homo sapiens
Sequence 2:	NP_525117.2	Gene:	Mgat1 / 37323	FlyBaseID:	FBgn0034521	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	221/410 - (53%)
Similarity:	279/410 - (68%)	Gaps:	24/410 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    36 RPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVT 100
            :||||::        |.::..:|.:...||..|.        ...|...|:||       :..:.
  Fly    73 QPPSVAS--------TPQISIIAAEISAELPEQH--------VAKSATARIPT-------KTYLA 114

Human   101 PAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQP 165
            ....|.|::|.||:|.:|::|:|.|:.||||.|.||||||||||.|.|.:||.|||..||.|.||
  Fly   115 NGEPVFPVVVFACNRVSVKKCIDNLVQYRPSVEQFPIIVSQDCGDEPTKEAILSYGKQVTLIEQP 179

Human   166 DLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLK 230
            |||.|.|.|..:||:|||||||||.|||...| ...|...::|||||.|||||||||..|:.|||
  Fly   180 DLSDITVLPKEKKFKGYYKIARHYGWALNTTF-AVGFEFVIIVEDDLNVAPDFFEYFLGTHKLLK 243

Human   231 ADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRP 295
            .|||||||||||||||..:|||::|||||||||||||||:|..:|||||..||||:|||||:|.|
  Fly   244 QDPSLWCVSAWNDNGKAAVVDAAQPELLYRTDFFPGLGWMLTKDLWAELSVKWPKSFWDDWIRHP 308

Human   296 EQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLA 360
            .||:.|.|||||||||.|||:.|||:|.|||::||.|||::.||.||::::|||.::.||..||.
  Fly   309 AQRKDRVCIRPEISRTRTFGKIGVSNGLFFDKYLKHIKLSEDFVQFTKINMSYLLKDNYDNTFLR 373

Human   361 RVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFR 425
            |||..|.:..:::|.|..:..|.||:|||.|:.:|...|.||:|||.||||||..|.|||:|.:.
  Fly   374 RVYTYPIVTYDELRRNLIRIEGPVRIQYTTREQYKRTTKMLGLMDDFKSGVPRTAYHGIVSFYYN 438

Human   426 GRRVHLAPPLTWEGYDPSWN 445
            .|||||||...|:||:.||:
  Fly   439 KRRVHLAPNANWKGYELSWS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MGAT1	NP_001108089.1	GNT-I	12..444	CDD:281116	219/407 (54%)
Mgat1	NP_525117.2	GT13_GLCNAC-TI	119..449	CDD:133007	203/330 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156973
Domainoid	1	1.000	445	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E1_KOG1413
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1804
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1631
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55205
OrthoDB	1	1.010	-	-		D1324622at2759
OrthoFinder	1	1.000	-	-		FOG0004830
OrthoInspector	1	1.000	-	-		oto90185
orthoMCL	1	0.900	-	-		OOG6_104509
Panther	1	1.100	-	-	LDO	PTHR10468
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3280
SonicParanoid	1	1.000	-	-		X3409
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800