DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep4 and ECE2

DIOPT Version :9

Sequence 1:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	774	Identity:	274/774 - (35%)
Similarity:	408/774 - (52%)	Gaps:	121/774 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 MDNKVDPCVDFYKYACGNWERLHPIPKDKAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKS 334
            :|..|.||.|||:::||.|.|.:|:|..::.::||..|.:....:|::||| ||..:|::|
Human   156 LDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLE-NTTFNSSSE---- 215

  Fly   335 PVRNTLFKLNEQGEGEGEADQAAELTAERLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPR 399

Human   216 ----------------------------------------------------------------- 215

  Fly   400 ERTKEEEAAPPVVLPKDKTKDKSDNEEQLHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLE 464
                                                     |:.|.:..|.||:....:.:.|.:
Human   216 -----------------------------------------AEQKTQRFYLSCLQVERIEELGAQ 239

  Fly   465 PLHTLIRELGGWPVLESQWSESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGL 529
            ||..||.::|||.: ...|.:.|| .:||.|....|........::.||.|:|..|::|.||:||
Human   240 PLRDLIEKIGGWNI-TGPWDQDNF-MEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGL 302

  Fly   530 GLPTREYFL-QPSNAKYLQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLN 593
            .||:|:|:| :.:|.|.|.||..||.|:...:|......:....:::..|.|||.||.|.:||.:
Human   303 FLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRD 367

  Fly   594 VTKLYKRMTLDQLQAVVPEIKWRAYLQ-SLQDREVLGTEEVVIYAVEYMSKLVTLLDETDPRTVS 657
            ..|:|.:|::.:|||:.|.:.|..:|. .|...|:..:|.||:|.::|:.::..|::.|:|..::
Human   368 EEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILN 432

  Fly   658 NYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREES-PQRWKVCIAQVNTNMGMAVGSMFVSRYF 721
            ||::|..|:...:::|.||:..::.....|:|.::| ..||:.||:..:..:|.|:||:||...|
Human   433 NYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATF 497

  Fly   722 DNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKVNAMSLKIGYPDFILNPSELNSKYA 786
            |..||.....|..:::.||.:.|....|:|:.|:|.|:||.:|:...||:|||||.|.||:..|.
Human   498 DRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYD 562

  Fly   787 GIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIMFPAGILQPP 851
            |.||..:.:|:|.||:...:||....:|.:..::..|...|..|||||...||:|:|||||||.|
Human   563 GYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAP 627

  Fly   852 FYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERARCIIAQYSN 916
            ||.|:.||:|||||||||:||||||.|||:||.:|:.||:..||.:.|:..|.....|:..||:.
Human   628 FYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQ 692

  Fly   917 YTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVSDEILPGLNMTGPQLFFLNFG 981
            |.|.  |..|||..|.||||||||||:.|::||:.||::|..|   :.||.:.:|..||||:.|.
Human   693 YQVN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEE---QQLPAVGLTNHQLFFVGFA 752

  Fly   982 QVWCGAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGSPMNPQKKCSVW 1040
            ||||....||:....|.|..|||.||||:||||||.||.|.|.||:||||||.:.|.||
Human   753 QVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep4	NP_650904.3	M13	274..1038	CDD:189000	270/766 (35%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	270/766 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150963
Domainoid	1	1.000	48	1.000	Domainoid score	I11915
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860